| Gene Symbol |
HSF1
|
| Entrez Gene |
3297
|
| Alt Symbol |
HSTF1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
heat shock transcription factor 1
|
| Other Description |
HSF 1|HSTF 1|heat shock factor protein 1
|
| Swissprots |
A8MW26 A8K4L0 Q53XT4 Q00613
|
| Accessions |
CAM91162 EAW82131 Q00613 AF299094 AAG23698 AK054762 BAG51421 AK125467 BAG54202 AK126580 AK222497 BAD96217 AK290975 BAF83664 AK300205 BAG61976 BC014638 AAH14638 BT007351 AAP36015 DA481620 DQ893859 ABM84785 M64673 AAA52695 XM_005272315 XP_005272372 XM_005272316 XP_005272373 XM_005272317 XP_005272374 XM_011517004 XP_011515306 XM_011517005 XP_011515307 XM_011517006 XP_011515308 XR_246618 NM_005526 NP_005517
|
| Function |
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. {ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12665592, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9535852}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth. On activation, translocates to nuclear stress granules. Colocalizes with SUMO1 in nuclear stress granules.
|
| Top Pathways |
Legionellosis
|
![Western Blot: HSF1 Overexpression Lysate (Adult Normal) [NBP2-07736] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HSF1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9863_HSF1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07736-img0001.jpg)