| Gene Symbol | HSF1 |
|---|---|
| Entrez Gene | 3297 |
| Alt Symbol | HSTF1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | heat shock transcription factor 1 |
| Other Description | HSF 1|HSTF 1|heat shock factor protein 1 |
| Swissprots | A8MW26 A8K4L0 Q53XT4 Q00613 |
| Accessions | CAM91162 EAW82131 Q00613 AF299094 AAG23698 AK054762 BAG51421 AK125467 BAG54202 AK126580 AK222497 BAD96217 AK290975 BAF83664 AK300205 BAG61976 BC014638 AAH14638 BT007351 AAP36015 DA481620 DQ893859 ABM84785 M64673 AAA52695 XM_005272315 XP_005272372 XM_005272316 XP_005272373 XM_005272317 XP_005272374 XM_011517004 XP_011515306 XM_011517005 XP_011515307 XM_011517006 XP_011515308 XR_246618 NM_005526 NP_005517 |
| Function | DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. {ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12665592, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9535852}. |
| Subcellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth. On activation, translocates to nuclear stress granules. Colocalizes with SUMO1 in nuclear stress granules. |
| Top Pathways | Legionellosis |