Gene Symbol | CERS4 |
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Entrez Gene | 79603 |
Alt Symbol | LASS4, Trh1 |
Species | Human |
Gene Type | protein-coding |
Description | ceramide synthase 4 |
Other Description | LAG1 homolog, ceramide synthase 4|LAG1 longevity assurance homolog 4 |
Swissprots | D6W665 Q9HA82 |
Accessions | EAW68940 EAW68941 EAW68942 EAW68943 EAW68944 EAW68945 Q9HA82 AK022151 BAB13972 AK055414 AK222621 BAD96341 AK225394 BC009828 AAH09828 BC063621 DA381485 DQ893215 ABM84141 DQ896544 ABM87543 XM_006722896 XP_006722959 XM_006722898 XP_006722961 XM_011528288 XP_011526590 XM_011528289 XP_011526591 XM_011528290 XP_011526592 XM_011528291 XP_011526593 XM_011528292 XP_011526594 XM_011528293 XP_011526595 XM_011528294 XP_011526596 XM_011528295 XP_011526597 XM_011528296 XP_011526598 NM_024552 NP_078828 |
Function | May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus membrane {ECO:0000255|PROSITE- ProRule:PRU00108}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Top Pathways | Sphingolipid signaling pathway, Sphingolipid metabolism |
LASS4 CRISPR/Cas9 KO Plasmid (h) - sc-406329 from Santa Cruz Biotechnology
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LASS4 HDR Plasmid (h) - sc-406329-HDR from Santa Cruz Biotechnology
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LASS4 Double Nickase Plasmid (h) - sc-406329-NIC from Santa Cruz Biotechnology
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LASS4 Double Nickase Plasmid (h2) - sc-406329-NIC-2 from Santa Cruz Biotechnology
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LASS4 CRISPR Activation Plasmid (h) - sc-406329-ACT from Santa Cruz Biotechnology
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LASS4 CRISPR Activation Plasmid (h2) - sc-406329-ACT-2 from Santa Cruz Biotechnology
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LASS4 Lentiviral Activation Particles (h) - sc-406329-LAC from Santa Cruz Biotechnology
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LASS4 Lentiviral Activation Particles (h2) - sc-406329-LAC-2 from Santa Cruz Biotechnology
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LASS4 siRNA (h) - sc-62549 from Santa Cruz Biotechnology
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LASS4 shRNA Plasmid (h) - sc-62549-SH from Santa Cruz Biotechnology
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LASS4 shRNA (h) Lentiviral Particles - sc-62549-V from Santa Cruz Biotechnology
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LASS4 RNAi - H00079603-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN11563 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11563 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01962 from Sigma-Aldrich
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CERS4 siRNA (Human) - CRJ2420 from Cohesion Biosciences
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CERS4 - MBS8222376 from MyBioSource
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shRNA set against Human Cers4 (NM_024552.2) - SHH262125 from Creative biogene
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Human CERS4 siRNA - orb272921 from Biorbyt
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CERS4 shRNA Plasmid (Human) - CHJ2420 from Cohesion Biosciences
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CERS4 miRNA 3'UTR clone - MiUTR3H-14432 from Creative biogene
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