CERS4

Gene Symbol	CERS4
Entrez Gene	79603
Alt Symbol	LASS4, Trh1
Species	Human
Gene Type	protein-coding
Description	ceramide synthase 4
Other Description	LAG1 homolog, ceramide synthase 4\|LAG1 longevity assurance homolog 4
Swissprots	D6W665 Q9HA82
Accessions	EAW68940 EAW68941 EAW68942 EAW68943 EAW68944 EAW68945 Q9HA82 AK022151 BAB13972 AK055414 AK222621 BAD96341 AK225394 BC009828 AAH09828 BC063621 DA381485 DQ893215 ABM84141 DQ896544 ABM87543 XM_006722896 XP_006722959 XM_006722898 XP_006722961 XM_011528288 XP_011526590 XM_011528289 XP_011526591 XM_011528290 XP_011526592 XM_011528291 XP_011526593 XM_011528292 XP_011526594 XM_011528293 XP_011526595 XM_011528294 XP_011526596 XM_011528295 XP_011526597 XM_011528296 XP_011526598 NM_024552 NP_078828
Function	May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus membrane {ECO:0000255\|PROSITE- ProRule:PRU00108}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Top Pathways	Sphingolipid signaling pathway, Sphingolipid metabolism

LASS4 (C-19) - sc-65112 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

LASS4 (C-19): sc-65112. Western blot analysis of LASS4 expression in LNCaP (A), PC-3 (B), SK-MEL-28 (C) and U-698-M (D) whole cell lysates.

LASS4 (D-6) - sc-376497 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

LASS4 (D-6): sc-376497. Western blot analysis of LASS4 expression in non-transfected: sc-117752 (A) and human LASS4 transfected: sc-173489 (B) 293T whole cell lysates.

LASS4 (F-15) - sc-65113 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

LASS4 (H-69) - sc-135036 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

LASS4 (H-69): sc-135036. Western blot analysis of LASS4 expression in HeLa (A), SK-MEL-28 (B) and U-698-M (C) whole cell lysates.

Anti-LASS4 antibody - ab70121 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

ab70121 at 1/50 dilution staining LASS4 in human brain by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.

Anti-LASS4 antibody - ab118379 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-LASS4 antibody (ab118379) at 5 µg/ml + HeLa cell lysate at 50 µg

Anti-LASS4 antibody - ab66512 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-LASS4 antibody (ab66512) at 2.5 µg/ml + NIH3T3 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-LASS4 antibody - C-terminal - ab186881 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-LASS4 antibody - C-terminal (ab186881) at 1 µg/ml + HT1080 whole cell lysate at 10 µg

Anti-LASS4 Antibody (aa49-98) - LS-C30939 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-LASS4 Antibody (aa57-140) - LS-C308720 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-LASS4 Antibody (N-Terminus) - LS-C110411 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

LASS4 antibody LS-C110411 Western blot of SH-SYSY lysate.

Anti-LASS4 Antibody (aa57-140, Azide-free) - LS-C327743 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal

Anti-LASS4 Antibody (C-Terminus) - LS-C80145 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

HepG2 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-LASS4 Antibody - LS-C140577 from LifeSpan Bioscience

Prices	$460.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of LAG1 longevity assurance homolog 4 (LS-C140577) at 0.75 ug/ml on human lung lysate14 ug/lane. Lane A] conjugate alone, Lane B] antibody plus 27 ug blocking peptide, Lane C] antibody alone. Visualized using Pierce West Femto substrate system. Anti Rabbit secondary used at 1:3.5K dilution. Exposure for 5 minutes

Anti-LASS4 Antibody - LS-C140578 from LifeSpan Bioscience

Prices	$360.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of LAG1 longevity assurance homolog 4 LS-C140578) at 0.75 ug/ml on human lung lysate14 ug/lane. Lane A] conjugate alone, Lane B] antibody plus 27 ug blocking peptide, Lane C] antibody alone. Visualized using Pierce West Femto substrate system. Anti Rabbit secondary used at 1:3.5K dilution. Exposure for 5 minutes

Anti-LASS4 Antibody (aa281-330) - LS-C205682 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

LASS4 antibody Western Blot of HT1080. Antibody dilution: 1 ug/ml.

Anti-LASS4 Antibody (aa41-90) - LS-C119271 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

IHC of paraffin-embedded human brain tissue, using LASS4 Antibody. The picture on the right is treated with the synthesized peptide.

LASS4 Antibody - NBP1-55731 from Novus Biologicals

Prices	$229.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: LASS4 Antibody [NBP1-55731] - Human neuroblastoma cell lines untreated or treated with various drugs. Image from verified customer review.

LASS4 Antibody (7D5) - H00079603-M03 from Novus Biologicals

Prices	$349.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	7D5

Western Blot: LASS4 Antibody (7D5) [H00079603-M03] - Western Blot analysis of LASS4 expression in HeLa ( Cat # L013V1 ).

LASS4 Antibody (7D1) - H00079603-M01 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	7D1

Western Blot: LASS4 Antibody (7D1) [H00079603-M01] - LASS4 monoclonal antibody (M01), clone 7D1 Analysis of LASS4 expression in HeLa.

LASS4 Antibody - NBP2-38735 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry: LASS4 Antibody [NBP2-38735] - Staining of human rectum shows strong cytoplasmic and nuclear positivity in inflammatory cells.

LASS4 Antibody (2G6) - H00079603-M04 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2G6

Western Blot: LASS4 Antibody (2G6) [H00079603-M04] - Analysis of LASS4 expression in HeLa (Cat # L013V1).

LASS4 Antibody (4B10) - H00079603-M02 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	4B10

Western Blot: LASS4 Antibody (4B10) [H00079603-M02] - Analysis of LASS4 expression in transfected 293T cell line by LASS4 monoclonal antibody (M02), clone 4B10.Lane 1: LASS4 transfected lysate(46.4 KDa).Lane 2: Non-transfected lysate.

LASS4 Antibody - H00079603-A01 from Novus Biologicals

Host	Mouse
Clonality	Polyclonal

LASS4 Antibody (2C12) - H00079603-M05 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2C12

Sandwich ELISA: LASS4 Antibody (2C12) [H00079603-M05] - Detection limit for recombinant GST tagged LASS4 is 0.03 ng/ml as a capture antibody.

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