GSAP

Gene Symbol GSAP
Entrez Gene 54103
Alt Symbol PION
Species Human
Gene Type protein-coding
Description gamma-secretase activating protein
Other Description gamma-secretase-activating protein|pigeon homolog|protein pigeon homolog
Swissprots Q9UMH3 Q9Y4L9 A4D1B6 Q8ND73 Q3MJC0 A4D1B5
Accessions A4D1B5 EAL24201 AK026696 AK026747 AK027188 AK126364 AL079277 CAB45152 AL079297 CAB45193 AL834358 CAD39023 BC101499 AAI01500 BC110797 BC143549 AAI43550 BM842423 DB498013 XM_011516325 XP_011514627 XM_011516326 XP_011514628 XM_011516327 XP_011514629 XM_011516328 XP_011514630 XM_011516329 XP_011514631 XM_011516330 XP_011514632 XM_011516331 XP_011514633 XM_011516332 XP_011514634 XR_927479 NM_017439 NP_059135
Function Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein (beta-amyloid protein 40 and beta-amyloid protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate beta- amyloid, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD. {ECO:0000269|PubMed:20811458}.
Subcellular Location Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:20811458}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:20811458}.

PION CRISPR/Cas9 KO Plasmid (h) - sc-406374 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PION HDR Plasmid (h) - sc-406374-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PION Double Nickase Plasmid (h) - sc-406374-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PION Double Nickase Plasmid (h2) - sc-406374-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PION CRISPR Activation Plasmid (h) - sc-406374-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PION CRISPR Activation Plasmid (h2) - sc-406374-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PION Lentiviral Activation Particles (h) - sc-406374-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PION Lentiviral Activation Particles (h2) - sc-406374-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PION siRNA (h) - sc-89397 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PION shRNA Plasmid (h) - sc-89397-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PION shRNA (h) Lentiviral Particles - sc-89397-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU022881 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16821 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16821 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05433 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05433

GSAP siRNA (Human) - CRJ0020 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GSAP - MBS8221573 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PION (NM_017439.3) - SHH375968 from Creative biogene

Category siRNA
Species Reactivities Human

GSAP shRNA Plasmid (Human) - CHJ0020 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PION miRNA 3'UTR clone - MiUTR1H-05835 from Creative biogene

Species Reactivities Human
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