GSAP

Gene Symbol GSAP
Entrez Gene 54103
Alt Symbol PION
Species Human
Gene Type protein-coding
Description gamma-secretase activating protein
Other Description gamma-secretase-activating protein|pigeon homolog|protein pigeon homolog
Swissprots Q9UMH3 Q9Y4L9 A4D1B6 Q8ND73 Q3MJC0 A4D1B5
Accessions A4D1B5 EAL24201 AK026696 AK026747 AK027188 AK126364 AL079277 CAB45152 AL079297 CAB45193 AL834358 CAD39023 BC101499 AAI01500 BC110797 BC143549 AAI43550 BM842423 DB498013 XM_011516325 XP_011514627 XM_011516326 XP_011514628 XM_011516327 XP_011514629 XM_011516328 XP_011514630 XM_011516329 XP_011514631 XM_011516330 XP_011514632 XM_011516331 XP_011514633 XM_011516332 XP_011514634 XR_927479 NM_017439 NP_059135
Function Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein (beta-amyloid protein 40 and beta-amyloid protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate beta- amyloid, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD. {ECO:0000269|PubMed:20811458}.
Subcellular Location Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:20811458}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:20811458}.

Rat GSAP / PION ELISA Kit (Sandwich ELISA) - LS-F8954 from LifeSpan Bioscience

Category ELISA Kit
Prices $860.00
Sizes 1 plate
Sensitivity 0.113 ng/ml
Range 0.313-20 ng/ml

Gamma-secretase-activating protein, PION, Human, ELISA Kit - E2079h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t
Range 1.56-100 ng/mL

Gamma-Secretase Activating Protein (gSAP), ELISA Kit - MBS2024242 from MyBioSource

Category ELISA Kit
Prices $435.00, $650.00, $895.00, $3,690.00, $6,650.00
Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity Typically less than 0.113ng/mL.
Range 0.313-20ng/mL

pigeon homolog (Drosophila) - MBS280569 from MyBioSource

Category ELISA Kit

ELISA Kit for Gamma-Secretase Activating Protein (gSAP) - SER761Ra from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.113ng/mL.
Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human GSAP / PION ELISA Kit (Custom ELISA) - LS-F19192 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 0.313-20 ng/ml

Mouse GSAP / PION ELISA Kit (Custom ELISA) - LS-F19191 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 0.313-20 ng/ml

Gamma-secretase-activating protein, ELISA Kit - MBS288161 from MyBioSource

Category ELISA Kit
Prices $380.00, $500.00, $2,170.00, $3,840.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Range 1.56 ng/mL -100 ng/mL.

PION - EKH4182 from Nordic BioSite

Sensitivity 0.938ng/ml
Range 1.56-100ng/ml

Human PION ELISA Kit - E016118 from Biobool

Category ELISA Kit

Human GSAP ELISA Kit - E084867 from Biobool

Category ELISA Kit

GSAP ELISA Kit (Human) (OKEH04772) - OKEH04772 from Aviva Systems Biology

Category ELISA Kit
Prices $425.00
Sizes 96 wells
Sensitivity < 0.78 ng/mL
Range 1.56 - 100 ng/mL

anti-GSAP / PION antibody - ARG54667 from Arigo Biolaboratories

Category ELISA Kit

Gamma-secretase-activating protein, ELISA Kit - MBS763580 from MyBioSource

Category ELISA Kit
Prices $295.00, $390.00, $1,615.00, $3,015.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.938ng/ml
Range 1.56-100ng/ml

Gamma-Secretase Activating Protein (GSAP), ELISA Kit - MBS9380198 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human GSAP / PION ELISA Kit (Sandwich ELISA) - LS-F36418 from LifeSpan Bioscience

Category ELISA Kit
Sensitivity 0.938
Range 0.313-20 ng/ml
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