| Gene Symbol |
GSAP
|
| Entrez Gene |
54103
|
| Alt Symbol |
PION
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
gamma-secretase activating protein
|
| Other Description |
gamma-secretase-activating protein|pigeon homolog|protein pigeon homolog
|
| Swissprots |
Q9UMH3 Q9Y4L9 A4D1B6 Q8ND73 Q3MJC0 A4D1B5
|
| Accessions |
A4D1B5 EAL24201 AK026696 AK026747 AK027188 AK126364 AL079277 CAB45152 AL079297 CAB45193 AL834358 CAD39023 BC101499 AAI01500 BC110797 BC143549 AAI43550 BM842423 DB498013 XM_011516325 XP_011514627 XM_011516326 XP_011514628 XM_011516327 XP_011514629 XM_011516328 XP_011514630 XM_011516329 XP_011514631 XM_011516330 XP_011514632 XM_011516331 XP_011514633 XM_011516332 XP_011514634 XR_927479 NM_017439 NP_059135
|
| Function |
Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein (beta-amyloid protein 40 and beta-amyloid protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate beta- amyloid, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD. {ECO:0000269|PubMed:20811458}.
|
| Subcellular Location |
Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:20811458}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:20811458}.
|