Gene Symbol | GSAP |
---|---|
Entrez Gene | 54103 |
Alt Symbol | PION |
Species | Human |
Gene Type | protein-coding |
Description | gamma-secretase activating protein |
Other Description | gamma-secretase-activating protein|pigeon homolog|protein pigeon homolog |
Swissprots | Q9UMH3 Q9Y4L9 A4D1B6 Q8ND73 Q3MJC0 A4D1B5 |
Accessions | A4D1B5 EAL24201 AK026696 AK026747 AK027188 AK126364 AL079277 CAB45152 AL079297 CAB45193 AL834358 CAD39023 BC101499 AAI01500 BC110797 BC143549 AAI43550 BM842423 DB498013 XM_011516325 XP_011514627 XM_011516326 XP_011514628 XM_011516327 XP_011514629 XM_011516328 XP_011514630 XM_011516329 XP_011514631 XM_011516330 XP_011514632 XM_011516331 XP_011514633 XM_011516332 XP_011514634 XR_927479 NM_017439 NP_059135 |
Function | Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein (beta-amyloid protein 40 and beta-amyloid protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate beta- amyloid, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD. {ECO:0000269|PubMed:20811458}. |
Subcellular Location | Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:20811458}. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:20811458}. |
PION (S-17) - sc-248257 from Santa Cruz Biotechnology
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PION (C-16) - sc-248258 from Santa Cruz Biotechnology
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Anti-PION antibody - ab106630 from Abcam
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Anti-PION antibody - ab113024 from Abcam
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Anti-GSAP / PION Antibody (Biotin) - LS-C180865 from LifeSpan Bioscience
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Anti-GSAP / PION Antibody (DY650) - LS-C180866 from LifeSpan Bioscience
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Anti-GSAP / PION Antibody (DY488) - LS-C180867 from LifeSpan Bioscience
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Anti-GSAP / PION Antibody (HRP) - LS-C180868 from LifeSpan Bioscience
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Anti-GSAP / PION Antibody (DY550) - LS-C180869 from LifeSpan Bioscience
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Anti-GSAP / PION Antibody (DY650) - LS-C180887 from LifeSpan Bioscience
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Anti-GSAP / PION Antibody (Biotin) - LS-C180886 from LifeSpan Bioscience
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Anti-GSAP / PION Antibody (DY550) - LS-C180890 from LifeSpan Bioscience
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Anti-GSAP / PION Antibody (DY488) - LS-C180888 from LifeSpan Bioscience
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Anti-GSAP / PION Antibody (HRP) - LS-C180889 from LifeSpan Bioscience
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Anti-GSAP / PION Antibody (aa536-565, AP) - LS-C239081 from LifeSpan Bioscience
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Anti-GSAP / PION Antibody (aa536-565, FITC) - LS-C239082 from LifeSpan Bioscience
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Anti-GSAP / PION Antibody (aa536-565, PE) - LS-C239084 from LifeSpan Bioscience
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Anti-GSAP / PION Antibody (aa536-565, APC) - LS-C239083 from LifeSpan Bioscience
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Anti-GSAP / PION Antibody (aa616-854, Biotin) - LS-C300714 from LifeSpan Bioscience
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Anti-GSAP / PION Antibody (aa616-854, FITC) - LS-C302125 from LifeSpan Bioscience
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Anti-GSAP / PION Antibody - LS-C180166 from LifeSpan Bioscience
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Anti-GSAP / PION Antibody (aa536-565) - LS-C329970 from LifeSpan Bioscience
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Anti-GSAP / PION Antibody (aa616-854) - LS-C294020 from LifeSpan Bioscience
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Anti-GSAP / PION Antibody (N-Terminus) - LS-C345463 from LifeSpan Bioscience
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Anti-GSAP / PION Antibody (C-Terminus) - LS-C305897 from LifeSpan Bioscience
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