NDC80

Gene Symbol NDC80
Entrez Gene 10403
Alt Symbol HEC, HEC1, HsHec1, KNTC2, TID3, hsNDC80
Species Human
Gene Type protein-coding
Description NDC80 kinetochore complex component
Other Description NDC80 homolog, kinetochore complex component|NDC80 kinetochore complex component homolog|highly expressed in cancer protein|highly expressed in cancer, rich in leucine heptad repeats|kinetochore associated 2|kinetochore protein Hec1|kinetochore protein NDC80 homolog|kinetochore-associated protein 2|retinoblastoma-associated protein HEC
Swissprots Q6PJX2 O14777
Accessions CAM84948 CCQ77692 CCQ77701 CCQ77710 CCQ77719 CDH48198 CDH61620 CDH61674 CDH61693 CDH88991 CDH92529 CDH92543 CDH92554 CDH92801 CDH92898 CDI44673 CDI44682 EAX01696 EAX01697 O14777 AF017790 AAB80726 AK289396 BAF82085 AK313184 BAG36001 BC005239 AAH05239 BC010171 BC035617 AAH35617 DQ890765 ABM81691 DQ893928 ABM84854 NM_006101 NP_006092
Function Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. {ECO:0000269|PubMed:12351790, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:9315664}.
Subcellular Location Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.

Hec1 CRISPR/Cas9 KO Plasmid (h) - sc-406844 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Hec1 HDR Plasmid (h) - sc-406844-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Hec1 Double Nickase Plasmid (h) - sc-406844-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Hec1 Double Nickase Plasmid (h2) - sc-406844-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Hec1 CRISPR Activation Plasmid (h) - sc-406844-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Hec1 CRISPR Activation Plasmid (h2) - sc-406844-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Hec1 Lentiviral Activation Particles (h) - sc-406844-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Hec1 Lentiviral Activation Particles (h2) - sc-406844-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Hec1 siRNA (h) - sc-37612 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Hec1 shRNA Plasmid (h) - sc-37612-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Hec1 shRNA (h) Lentiviral Particles - sc-37612-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU042171 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15117 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15117 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NDC80 siRNA (Human) - CRH7052 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NDC80 RNAi - H00010403-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human NDC80 (NM_006101.2) - SHH350252 from Creative biogene

Category siRNA
Species Reactivities Human

Hec1 CRISPR/Cas9 KO Plasmid (h2) - sc-406844-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Hec1 HDR Plasmid (h2) - sc-406844-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NDC80 siRNA - orb219198 from Biorbyt

Category siRNA
Prices $417.00
Sizes 5 od (260 nm)
Species Reactivities Human

Human NDC80 siRNA - orb267554 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NDC80 shRNA Plasmid (Human) - CHH7052 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NDC80 miRNA 3'UTR clone - MiUTR3H-09103 from Creative biogene

Species Reactivities Human
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