| Gene Symbol |
NDC80
|
| Entrez Gene |
10403
|
| Alt Symbol |
HEC, HEC1, HsHec1, KNTC2, TID3, hsNDC80
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NDC80 kinetochore complex component
|
| Other Description |
NDC80 homolog, kinetochore complex component|NDC80 kinetochore complex component homolog|highly expressed in cancer protein|highly expressed in cancer, rich in leucine heptad repeats|kinetochore associated 2|kinetochore protein Hec1|kinetochore protein NDC80 homolog|kinetochore-associated protein 2|retinoblastoma-associated protein HEC
|
| Swissprots |
Q6PJX2 O14777
|
| Accessions |
CAM84948 CCQ77692 CCQ77701 CCQ77710 CCQ77719 CDH48198 CDH61620 CDH61674 CDH61693 CDH88991 CDH92529 CDH92543 CDH92554 CDH92801 CDH92898 CDI44673 CDI44682 EAX01696 EAX01697 O14777 AF017790 AAB80726 AK289396 BAF82085 AK313184 BAG36001 BC005239 AAH05239 BC010171 BC035617 AAH35617 DQ890765 ABM81691 DQ893928 ABM84854 NM_006101 NP_006092
|
| Function |
Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. {ECO:0000269|PubMed:12351790, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:9315664}.
|
| Subcellular Location |
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.
|