Gene Symbol | MAPK4 |
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Entrez Gene | 5596 |
Alt Symbol | ERK-4, ERK4, PRKM4, p63-MAPK, p63MAPK |
Species | Human |
Gene Type | protein-coding |
Description | mitogen-activated protein kinase 4 |
Other Description | Erk3-related|MAP kinase isoform p63|MAPK 4|extracellular signal-regulated kinase 4 |
Swissprots | A1A4C4 P31152 Q0VG04 |
Accessions | EAW62976 EAW62977 P31152 AA771957 AI088913 AK293818 BAG57223 AK295058 BAG58107 AK303601 BAG64616 BC040493 BC050299 AAH50299 BC117216 AAI17217 BC143769 BX648603 HQ258629 ADR83381 X59727 CAA42411 XM_005258299 XP_005258356 XM_011526074 XP_011524376 XM_011526075 XP_011524377 XM_011526076 XP_011524378 XM_011526077 XP_011524379 XM_011526078 XP_011524380 NM_001292039 NP_001278968 NM_001292040 NP_001278969 NM_002747 NP_002738 |
Function | Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates to the cytoplasm following interaction with MAPKAPK5. {ECO:0000250}. |
Tissue Specificity | High expression in heart and brain. |
Human MAPK4 protein fragment - ab159216 from Abcam
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MAPK4 / ERK4 Antibody Blocking Peptide - LS-E3288 from LifeSpan Bioscience
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MAPK4 / ERK4 Antibody Blocking Peptide - LS-E20486 from LifeSpan Bioscience
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MAPK4 / ERK4 Antibody Blocking Peptide - LS-E9010 from LifeSpan Bioscience
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Recombinant Human ERK4/MAPK4 Protein - H00005596-Q01 from Novus Biologicals
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ERK4/MAPK4 Peptide - P2503 from Novus Biologicals
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ERK4/MAPK4 Peptide - P2485 from Novus Biologicals
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MAPK4-Antibody-C-term-Blocking-Peptide - BP7298b from Abgent, a WuXi AppTec company
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MAPK4-Antibody-N-term-Blocking-Peptide - BP7298a from Abgent, a WuXi AppTec company
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ERK4-Antibody-C-term-Blocking-Peptide - BP7503a from Abgent, a WuXi AppTec company
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MAPK4 Blocking Peptide - 33R-1930 from Fitzgerald
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MAPK4 / ERK4 - H00005596-Q01-10 from Acris Antibodies
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MAPK4 / ERK4 - H00005596-Q01-25 from Acris Antibodies
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MAPK4 fusion protein - Ag22899 from Proteintech Group
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Recombinant Human Mitogen-activated protein kinase 4(MAPK4) - CSB-YP013457HU CSB-EP013457HU CSB-BP013457HU CSB-MP013457HU from Cusabio
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MAPK4 Protein - abx163474 from Abbexa
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MAPK4 / ERK4 - TP307414 from Acris Antibodies
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ERK4/MAPK4 Protein - NBP1-84805PEP from Novus Biologicals
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MAPK4 Peptide, Human - M34GP09202H from Creative Peptides
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MAPK4 peptide - orb72949 from Biorbyt
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Mitogen-activated protein kinase 4 (MAPK4), Recombinant Protein - MBS951360 from MyBioSource
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