| Gene Symbol |
MAPK4
|
| Entrez Gene |
5596
|
| Alt Symbol |
ERK-4, ERK4, PRKM4, p63-MAPK, p63MAPK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase 4
|
| Other Description |
Erk3-related|MAP kinase isoform p63|MAPK 4|extracellular signal-regulated kinase 4
|
| Swissprots |
A1A4C4 P31152 Q0VG04
|
| Accessions |
EAW62976 EAW62977 P31152 AA771957 AI088913 AK293818 BAG57223 AK295058 BAG58107 AK303601 BAG64616 BC040493 BC050299 AAH50299 BC117216 AAI17217 BC143769 BX648603 HQ258629 ADR83381 X59727 CAA42411 XM_005258299 XP_005258356 XM_011526074 XP_011524376 XM_011526075 XP_011524377 XM_011526076 XP_011524378 XM_011526077 XP_011524379 XM_011526078 XP_011524380 NM_001292039 NP_001278968 NM_001292040 NP_001278969 NM_002747 NP_002738
|
| Function |
Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates to the cytoplasm following interaction with MAPKAPK5. {ECO:0000250}.
|
| Tissue Specificity |
High expression in heart and brain.
|