Gck

Gene Symbol Gck
Entrez Gene 103988
Alt Symbol GLK, Gk, Gls006, HK4, HKIV, HXKP, Hlb62, MODY2
Species Mouse
Gene Type protein-coding
Description glucokinase
Other Description HK IV|hexokinase 4|hexokinase type IV|hexokinase-4|hexokinase-D
Swissprots P52791 P52792
Accessions AAC42074 BAJ19146 BAJ19147 BAJ19148 BAJ19149 CBF63183 CBU88059 EDL40567 EDL40568 P52792 AK142698 BC011139 AAH11139 L38988 AAB00359 L38990 AAB00360 M58755 AAA37703 XM_006514443 XP_006514506 XM_006514444 XP_006514507 NM_001287386 NP_001274315 NM_010292 NP_034422
Function Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Under low glucose concentrations, GCK associates with GKRP and the inactive complex is recruited to the hepatocyte nucleus. {ECO:0000250}.
Tissue Specificity Pancreas, anterior pituitary (isoform 1) and liver (isoform 2).
Top Pathways Glucagon signaling pathway, Central carbon metabolism in cancer, Prolactin signaling pathway, Insulin signaling pathway, Glycolysis / Gluconeogenesis

GCK CRISPR/Cas9 KO Plasmid (m) - sc-430501 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

GCK HDR Plasmid (m) - sc-430501-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

GCK Double Nickase Plasmid (m) - sc-430501-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

GCK Double Nickase Plasmid (m2) - sc-430501-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

GCK CRISPR Activation Plasmid (m) - sc-430501-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

GCK CRISPR Activation Plasmid (m2) - sc-430501-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

GCK Lentiviral Activation Particles (m) - sc-430501-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

GCK Lentiviral Activation Particles (m2) - sc-430501-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

GCK siRNA (m) - sc-35459 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

GCK shRNA Plasmid (m) - sc-35459-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

GCK shRNA (m) Lentiviral Particles - sc-35459-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

CompoZr® Knockout ZFN Kit - CKOZFN31789 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31789 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

GCK siRNA (Mouse) - CRN0637 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

GCK - MBS8236764 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse GCK (NM_010292.4) - SHH300026 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Gck(NM_010292.4) - SHH079859 from Creative biogene

Category siRNA
Species Reactivities Mouse

GCK shRNA Plasmid (Mouse) - CHN0637 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

GCK miRNA 3'UTR clone - MiUTR1M-04977 from Creative biogene

Species Reactivities Mouse
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