| Gene Symbol |
Gck
|
| Entrez Gene |
103988
|
| Alt Symbol |
GLK, Gk, Gls006, HK4, HKIV, HXKP, Hlb62, MODY2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
glucokinase
|
| Other Description |
HK IV|hexokinase 4|hexokinase type IV|hexokinase-4|hexokinase-D
|
| Swissprots |
P52791 P52792
|
| Accessions |
AAC42074 BAJ19146 BAJ19147 BAJ19148 BAJ19149 CBF63183 CBU88059 EDL40567 EDL40568 P52792 AK142698 BC011139 AAH11139 L38988 AAB00359 L38990 AAB00360 M58755 AAA37703 XM_006514443 XP_006514506 XM_006514444 XP_006514507 NM_001287386 NP_001274315 NM_010292 NP_034422
|
| Function |
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Under low glucose concentrations, GCK associates with GKRP and the inactive complex is recruited to the hepatocyte nucleus. {ECO:0000250}.
|
| Tissue Specificity |
Pancreas, anterior pituitary (isoform 1) and liver (isoform 2).
|
| Top Pathways |
Glucagon signaling pathway, Central carbon metabolism in cancer, Prolactin signaling pathway, Insulin signaling pathway, Glycolysis / Gluconeogenesis
|