| Gene Symbol |
AQR
|
| Entrez Gene |
9716
|
| Alt Symbol |
IBP160, fSAP164
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
aquarius intron-binding spliceosomal factor
|
| Other Description |
aquarius homolog|functional spliceosome-associated protein 164|intron-binding protein aquarius|intron-binding protein of 160 kDa
|
| Swissprots |
A5YKK3 A0JP17 O60306 Q6IRU8 Q2YDX9 Q6PIC8
|
| Accessions |
EAW92319 EAW92320 EAW92321 O60306 AB011132 BAA25486 AK001173 AK291615 BAF84304 AK315815 BAF98706 AL703893 BC027452 BC036913 AAH36913 BC070379 AAH70379 BC108262 AAI08263 BC127111 AAI27112 BC127112 AAI27113 BX647820 BX648611 EF553519 ABQ66265 NM_014691 NP_055506
|
| Function |
Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. {ECO:0000269|PubMed:16949364}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16949364}. Note=Localizes to speckle-like regions of the nucleoplasm. {ECO:0000269|PubMed:16949364}.
|
| Top Pathways |
Spliceosome
|