Gene Symbol | ID4 |
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Entrez Gene | 3400 |
Alt Symbol | IDB4, bHLHb27 |
Species | Human |
Gene Type | protein-coding |
Description | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein |
Other Description | DNA-binding protein inhibitor ID-4|class B basic helix-loop-helix protein 27|inhibitor of differentiation 4 |
Swissprots | Q13005 P47928 |
Accessions | AAC39674 EAW55416 P47928 AI692586 AJ420553 AK130851 BC014941 AAH14941 DB461864 U16153 AAA82882 U28368 AAA73923 Y07958 CAA69255 NM_001546 NP_001537 |
Function | Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus. |
Top Pathways | TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells |
Id4 CRISPR/Cas9 KO Plasmid (h) - sc-401380 from Santa Cruz Biotechnology
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Id4 HDR Plasmid (h) - sc-401380-HDR from Santa Cruz Biotechnology
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Id4 Double Nickase Plasmid (h) - sc-401380-NIC from Santa Cruz Biotechnology
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Id4 Double Nickase Plasmid (h2) - sc-401380-NIC-2 from Santa Cruz Biotechnology
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Id4 CRISPR Activation Plasmid (h) - sc-401380-ACT from Santa Cruz Biotechnology
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Id4 CRISPR Activation Plasmid (h2) - sc-401380-ACT-2 from Santa Cruz Biotechnology
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Id4 Lentiviral Activation Particles (h) - sc-401380-LAC from Santa Cruz Biotechnology
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Id4 Lentiviral Activation Particles (h2) - sc-401380-LAC-2 from Santa Cruz Biotechnology
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Id4 siRNA (h) - sc-38004 from Santa Cruz Biotechnology
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Id4 shRNA Plasmid (h) - sc-38004-SH from Santa Cruz Biotechnology
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Id4 shRNA (h) Lentiviral Particles - sc-38004-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN10440 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10440 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09249 from Sigma-Aldrich
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ID4 siRNA (Human) - CRH2310 from Cohesion Biosciences
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ID4 RNAi - H00003400-R01 from Novus Biologicals
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ID4 - MBS8217941 from MyBioSource
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shRNA set against Human ID4 (NM_001546.3) - SHH316533 from Creative biogene
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Id4 CRISPR/Cas9 KO Plasmid (h2) - sc-401380-KO-2 from Santa Cruz Biotechnology
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Id4 HDR Plasmid (h2) - sc-401380-HDR-2 from Santa Cruz Biotechnology
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Human ID4 siRNA - orb262812 from Biorbyt
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ID4 shRNA Plasmid (Human) - CHH2310 from Cohesion Biosciences
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ID4 miRNA 3'UTR clone - MiUTR3H-03493 from Creative biogene
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