Otub1

Gene Symbol	Otub1
Entrez Gene	107260
Alt Symbol	AI850305
Species	Mouse
Gene Type	protein-coding
Description	OTU domain, ubiquitin aldehyde binding 1
Other Description	OTU domain-containing ubiquitin aldehyde-binding protein 1|deubiquitinating enzyme OTUB1|otubain 1|otubain-1|ubiquitin thioesterase OTUB1|ubiquitin-specific-processing protease OTUB1
Swissprots	Q3ULV9 Q7TQI3 Q8C326 Q8R5F2 Q3V408
Accessions	EDL33291 Q7TQI3 AK027996 BAE20433 AK087195 AK140070 BAE24227 AK145273 BAE26339 AK145970 BAE26795 AK191684 AK217174 BC022575 AAH22575 BC054410 AAH54410 NM_134150 NP_598911
Function	Hydrolase that can specifically remove compared to 'Lys- 48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'- linked ubiquitin. {ECO:0000269|PubMed:14661020}.
Subcellular Location	Cytoplasm {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Mouse Otubain 1 Protein - abx068409 from Abbexa Category Protein Source E.coli Species Mouse

Otubain 1 (OTUB1), Mouse - 20-9491 from ARP American Research Products Category Protein Prices $489.00 Sizes 50 µg Source E.coli Species Mouse

Recombinant Otubain 1 (OTUB1) - RPL838Mu01 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Mouse Ubiquitin thioesterase OTUB1(Otub1) - CSB-YP742515MO CSB-EP742515MO CSB-BP742515MO CSB-MP742515MO from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Mouse

Otubain 1 (OTUB1) - RPU143164 from Biomatik Category Protein Prices $231.00, $462.00, $693.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Mouse

Recombinant Mouse OTUB1 Protein - OTUB1-12237M from Creative Biomart Category Protein Source Mammalian Cells Species Mouse

Recombinant Otubain 1 (OTUB1) - RPU43164 from Biomatik Category Protein Prices $185.00, $378.00, $578.00, $688.80 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Mouse

OTUB1 Recombinant Protein (OPCD05933) - OPCD05933 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

Otubain 1 (OTUB1), Recombinant Protein - MBS2011767 from MyBioSource Category Protein Prices $185.00, $380.00, $585.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

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