| Gene Symbol |
Otub1
|
| Entrez Gene |
107260
|
| Alt Symbol |
AI850305
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
OTU domain, ubiquitin aldehyde binding 1
|
| Other Description |
OTU domain-containing ubiquitin aldehyde-binding protein 1|deubiquitinating enzyme OTUB1|otubain 1|otubain-1|ubiquitin thioesterase OTUB1|ubiquitin-specific-processing protease OTUB1
|
| Swissprots |
Q3ULV9 Q7TQI3 Q8C326 Q8R5F2 Q3V408
|
| Accessions |
EDL33291 Q7TQI3 AK027996 BAE20433 AK087195 AK140070 BAE24227 AK145273 BAE26339 AK145970 BAE26795 AK191684 AK217174 BC022575 AAH22575 BC054410 AAH54410 NM_134150 NP_598911
|
| Function |
Hydrolase that can specifically remove compared to 'Lys- 48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'- linked ubiquitin. {ECO:0000269|PubMed:14661020}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|