| Gene Symbol | COPG1 |
|---|---|
| Entrez Gene | 22820 |
| Alt Symbol | COPG |
| Species | Human |
| Gene Type | protein-coding |
| Description | coatomer protein complex, subunit gamma 1 |
| Other Description | coat protein gamma-cop|coatomer subunit gamma|coatomer subunit gamma-1|gamma-1-COP|gamma-1-coat protein|gamma-COP|gamma-coat protein |
| Swissprots | A8K6M8 B3KMF6 Q54AC4 Q9Y678 |
| Accessions | EAW79267 EAW79268 EAW79269 EAW79270 Q9Y678 AB047846 BAB17657 AF100756 AAD43020 AK001724 BAG50968 AK024721 AK025147 AK123939 BAG53983 AK291693 BAF84382 AK309821 BC020498 AAH20498 BC066650 AAH66650 BU521557 XM_011512549 XP_011510851 NM_016128 NP_057212 |
| Function | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11056392}. Golgi apparatus membrane {ECO:0000269|PubMed:11056392}; Peripheral membrane protein {ECO:0000269|PubMed:11056392}; Cytoplasmic side {ECO:0000269|PubMed:11056392}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Predominantly located in the cis-Golgi apparatus. {ECO:0000250}. |
COPG CRISPR/Cas9 KO Plasmid (h) - sc-404407 from Santa Cruz Biotechnology
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COPG HDR Plasmid (h) - sc-404407-HDR from Santa Cruz Biotechnology
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COPG Double Nickase Plasmid (h) - sc-404407-NIC from Santa Cruz Biotechnology
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COPG Double Nickase Plasmid (h2) - sc-404407-NIC-2 from Santa Cruz Biotechnology
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COPG CRISPR Activation Plasmid (h) - sc-404407-ACT from Santa Cruz Biotechnology
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COPG CRISPR Activation Plasmid (h2) - sc-404407-ACT-2 from Santa Cruz Biotechnology
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COPG Lentiviral Activation Particles (h) - sc-404407-LAC from Santa Cruz Biotechnology
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COPG Lentiviral Activation Particles (h2) - sc-404407-LAC-2 from Santa Cruz Biotechnology
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COPG siRNA (h) - sc-37254 from Santa Cruz Biotechnology
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COPG shRNA Plasmid (h) - sc-37254-SH from Santa Cruz Biotechnology
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COPG shRNA (h) Lentiviral Particles - sc-37254-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU008521 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6429 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6429 from Sigma-Aldrich
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COPG1 siRNA (Human) - CRH7788 from Cohesion Biosciences
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COPG1 - MBS8214725 from MyBioSource
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COPG CRISPR/Cas9 KO Plasmid (h2) - sc-404407-KO-2 from Santa Cruz Biotechnology
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COPG HDR Plasmid (h2) - sc-404407-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human COPG (NM_016128.3) - SHH267773 from Creative biogene
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shRNA set against Human COPG(NM_016128.3) - SHG192547 from Creative biogene
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COPG1 shRNA Plasmid (Human) - CHH7788 from Cohesion Biosciences
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COPG1 miRNA 3'UTR clone - MiUTR1H-02356 from Creative biogene
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