| Gene Symbol |
COPG1
|
| Entrez Gene |
22820
|
| Alt Symbol |
COPG
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
coatomer protein complex, subunit gamma 1
|
| Other Description |
coat protein gamma-cop|coatomer subunit gamma|coatomer subunit gamma-1|gamma-1-COP|gamma-1-coat protein|gamma-COP|gamma-coat protein
|
| Swissprots |
A8K6M8 B3KMF6 Q54AC4 Q9Y678
|
| Accessions |
EAW79267 EAW79268 EAW79269 EAW79270 Q9Y678 AB047846 BAB17657 AF100756 AAD43020 AK001724 BAG50968 AK024721 AK025147 AK123939 BAG53983 AK291693 BAF84382 AK309821 BC020498 AAH20498 BC066650 AAH66650 BU521557 XM_011512549 XP_011510851 NM_016128 NP_057212
|
| Function |
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11056392}. Golgi apparatus membrane {ECO:0000269|PubMed:11056392}; Peripheral membrane protein {ECO:0000269|PubMed:11056392}; Cytoplasmic side {ECO:0000269|PubMed:11056392}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Predominantly located in the cis-Golgi apparatus. {ECO:0000250}.
|
![Western Blot: COPG Overexpression Lysate (Adult Normal) [NBL1-09379] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for COPG.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/13690_COPG%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-09379-img0002.jpg)