EME1

Gene Symbol	EME1
Entrez Gene	146956
Alt Symbol	MMS4L, SLX2A
Species	Human
Gene Type	protein-coding
Description	essential meiotic structure-specific endonuclease 1
Other Description	MMS4 homolog|SLX2 structure-specific endonuclease subunit homolog A|crossover junction endonuclease EME1|essential meiotic endonuclease 1 homolog 1|essential meiotic endonuclease 1 homolog 2|hMMS4|homolog of yeast EME1 endonuclease
Swissprots	Q96N62 Q96AY2
Accessions	EAW94617 EAW94618 EAW94619 EAW94620 EAW94621 Q96AY2 AK021607 AK055926 BAB71047 AK308275 BC016470 AAH16470 DA006645 DB245967 DQ578819 JF432239 ADZ15456 XM_005257081 XP_005257138 XM_011524392 XP_011522694 XM_011524393 XP_011522695 XM_011524394 XP_011522696 XM_011524395 XP_011522697 XM_011524396 XP_011522698 XR_934390 XR_934392 XR_934393 NM_001166131 NP_001159603 NM_152463 NP_689676
Function	Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'- flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. {ECO:0000269|PubMed:12686547, ECO:0000269|PubMed:12721304, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:17289582}.
Subcellular Location	Nucleus, nucleolus {ECO:0000269|PubMed:14617801}. Note=Recruited to regions of DNA damage in S-phase cells.
Top Pathways	Homologous recombination, Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EME1 full length protein - ab165544 from Abcam Category Protein Source Wheat germ Species Human

EME1 Antibody Blocking Peptide - LS-E19106 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EME1 Antibody Blocking Peptide - LS-E19107 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human EME1 Protein - H00146956-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Human EME1 protein - orb246277 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

EME1 Blocking Peptide - 33R-5688 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EME1 Blocking Peptide - 33R-1632 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EME1 / MMS4 - H00146956-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EME1 / MMS4 - H00146956-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

EME1 fusion protein - Ag3580 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human EME1, GST-tagged - EME1-12431H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Crossover junction endonuclease EME1(EME1) - CSB-YP856897HU CSB-BP856897HU CSB-MP856897HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Crossover junction endonuclease EME1 - CSB-EP856897HU from Cusabio Category Protein Source E.coli Species Human

EME1 Protein - abx163626 from Abbexa Category Protein Species Mouse, Rat

EME1-Antibody-Center-Blocking-Peptide - BP6288c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EME1-Antibody-N-term-Blocking-Peptide - BP6288a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EME1 Peptide, Human - M34GP04901H from Creative Peptides Category Peptide Source Synthetic. Species Human

EME1 Recombinant Protein (OPCA02440) - OPCA02440 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Recombinant human Crossover junction endonuclease EME1 - AP71490 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Crossover junction endonuclease EME1, Recombinant Protein - MBS9421354 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E Coli Species Human

Crossover junction endonuclease EME1, Recombinant Protein - MBS1417794 from MyBioSource Category Protein Prices $190.00, $460.00, $750.00, $1,180.00, $1,370.00, $1,585.00, $1,585.00, $2,275.00, $2,740.00, $2,740.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 1 mg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Recombinant Human Crossover junction endonuclease EME1 (EME1) - RPC23492 from Biomatik Category Protein Prices $187.00, $342.00, $1,692.00 Sizes 50 µg, 100 µg, 1 mg Source E.coli Species Human

Recombinant Human EME1 Protein (1-583 aa), His-SUMO-tagged - EME1-1106H from Creative Biomart Category Protein Source E. coli Species Human

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