| Gene Symbol |
EME1
|
| Entrez Gene |
146956
|
| Alt Symbol |
MMS4L, SLX2A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
essential meiotic structure-specific endonuclease 1
|
| Other Description |
MMS4 homolog|SLX2 structure-specific endonuclease subunit homolog A|crossover junction endonuclease EME1|essential meiotic endonuclease 1 homolog 1|essential meiotic endonuclease 1 homolog 2|hMMS4|homolog of yeast EME1 endonuclease
|
| Swissprots |
Q96N62 Q96AY2
|
| Accessions |
EAW94617 EAW94618 EAW94619 EAW94620 EAW94621 Q96AY2 AK021607 AK055926 BAB71047 AK308275 BC016470 AAH16470 DA006645 DB245967 DQ578819 JF432239 ADZ15456 XM_005257081 XP_005257138 XM_011524392 XP_011522694 XM_011524393 XP_011522695 XM_011524394 XP_011522696 XM_011524395 XP_011522697 XM_011524396 XP_011522698 XR_934390 XR_934392 XR_934393 NM_001166131 NP_001159603 NM_152463 NP_689676
|
| Function |
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'- flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. {ECO:0000269|PubMed:12686547, ECO:0000269|PubMed:12721304, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:17289582}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:14617801}. Note=Recruited to regions of DNA damage in S-phase cells.
|
| Top Pathways |
Homologous recombination, Fanconi anemia pathway
|
