Gene Symbol | TNFRSF12A |
---|---|
Entrez Gene | 51330 |
Alt Symbol | CD266, FN14, TWEAKR |
Species | Human |
Gene Type | protein-coding |
Description | tumor necrosis factor receptor superfamily, member 12A |
Other Description | FGF-inducible 14|fibroblast growth factor-inducible immediate-early response protein 14|tumor necrosis factor receptor superfamily member 12A|tweak-receptor|type I transmembrane protein Fn14 |
Swissprots | Q9NP84 Q9HCS0 D3DUA6 |
Accessions | CAI54172 CAL48784 CCA61735 CCA61738 EAW85428 EAW85429 EAW85430 Q9NP84 AB035480 BAA94792 AB035481 BAB17850 AF191148 AAF69108 BC002718 AAH02718 BC020538 BC064377 BM842283 DQ892968 ABM83894 DQ896216 ABM87215 NM_016639 NP_057723 |
Function | Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. {ECO:0000269|PubMed:11728344}. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. |
Top Pathways | Cytokine-cytokine receptor interaction |