| Gene Symbol |
TNFRSF12A
|
| Entrez Gene |
51330
|
| Alt Symbol |
CD266, FN14, TWEAKR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tumor necrosis factor receptor superfamily, member 12A
|
| Other Description |
FGF-inducible 14|fibroblast growth factor-inducible immediate-early response protein 14|tumor necrosis factor receptor superfamily member 12A|tweak-receptor|type I transmembrane protein Fn14
|
| Swissprots |
Q9NP84 Q9HCS0 D3DUA6
|
| Accessions |
CAI54172 CAL48784 CCA61735 CCA61738 EAW85428 EAW85429 EAW85430 Q9NP84 AB035480 BAA94792 AB035481 BAB17850 AF191148 AAF69108 BC002718 AAH02718 BC020538 BC064377 BM842283 DQ892968 ABM83894 DQ896216 ABM87215 NM_016639 NP_057723
|
| Function |
Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. {ECO:0000269|PubMed:11728344}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.
|
| Top Pathways |
Cytokine-cytokine receptor interaction
|
