F12

Gene Symbol	F12
Entrez Gene	2161
Alt Symbol	HAE3, HAEX, HAF
Species	Human
Gene Type	protein-coding
Description	coagulation factor XII (Hageman factor)
Other Description	Hageman factor|beta-factor XIIa part 1|beta-factor XIIa part 2|coagulation factor XII|coagulation factor XIIa heavy chain|coagulation factor XIIa light chain
Swissprots	P78339 P00748
Accessions	AAB51203 AAB51204 AAB51205 AAB51206 AAB51207 AAB59490 AAB59491 AAM97932 CAK18991 EAW85002 EAW85003 EAW85004 EAW85005 P00748 AB095845 BAC23095 BC012390 AAH12390 BC168381 AAI68381 BE139501 BT007350 AAP36014 M11723 AAA51986 M13147 AAA70224 M31315 AAA70225 XM_011534461 XP_011532763 XM_011534462 XP_011532764 NM_000505 NP_000496
Function	Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. {ECO:0000269|PubMed:21304106}.
Subcellular Location	Secreted.
Top Pathways	Complement and coagulation cascades

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Factor alpha XIIa full length protein - ab183263 from Abcam Category Protein Prices $487.00 Sizes 50 µg Source Insect cells Species Human

Active human Factor XII full length protein - ab183261 from Abcam Category Protein Prices $332.00 Sizes 50 µg Source Insect cells Species Human

Active mouse Factor alpha XIIa full length protein - ab170080 from Abcam Category Protein Prices $352.00 Sizes 50 µg Source Insect cells Species Mouse

Human Factor XII full length protein - ab158410 from Abcam Category Protein Source Wheat germ Species Human

Human Factor XII full length protein - ab158411 from Abcam Category Protein Source Wheat germ Species Human

Human Factor XII full length protein - ab168873 from Abcam Category Protein Source Native Species Human

Human Factor XII full length protein - ab62423 from Abcam Category Protein Source Native Species Human

Human Factor XII protein fragment - ab158412 from Abcam Category Protein Source Wheat germ Species Human

Mouse Factor XII full length protein - ab170085 from Abcam Category Protein Source Insect cells Species Mouse

F12 / Factor XII Antibody Blocking Peptide - LS-E6514 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

F12 / Factor XII Antibody Blocking Peptide - LS-E10254 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

F12 / Factor XII Antibody Blocking Peptide - LS-E15363 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Factor XII heavy chain Protein - H00002161-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Factor XII heavy chain Protein - H00002161-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Factor XII heavy chain Protein - H00002161-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

F12-Antibody-N-term-Blocking-Peptide - BP19282a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

F12-Antibody-N-term-Blocking-Peptide - BP9668a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human Coagulation Factor XII Protein - abx065987 from Abbexa Category Protein Source E.coli Species Human

Coagulation factor XII (F12) - H00002161-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Coagulation factor XII (F12) - H00002161-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Coagulation factor XII (F12) - H00002161-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

Coagulation factor XII (F12) - H00002161-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Coagulation factor XII (F12) - H00002161-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Coagulation factor XII (F12) - H00002161-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Coagulation factor XII (F12) - H00002161-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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