PLAT

Gene Symbol	PLAT
Entrez Gene	5327
Alt Symbol	T-PA, TPA
Species	Human
Gene Type	protein-coding
Description	plasminogen activator, tissue
Other Description	alteplase|plasminogen activator, tissue type|reteplase|t-plasminogen activator|tissue plasminogen activator (t-PA)|tissue-type plasminogen activator
Swissprots	A8K022 Q9BU99 Q86YK8 Q9BZW1 Q7Z7N2 B2R8E8 Q503B0 P00750 Q15103 Q6PJA5
Accessions	AAA61213 AAA98809 AAB59510 AAP34246 CAA00166 CAA54669 CAJ18783 CAL48222 EAW63231 EAW63232 EAW63233 EAW63234 EAW63235 P00750 A03776 CAA00299 A07197 CAA00642 AF260825 AAK11956 AF282882 AAM52248 AK289387 BAF82076 AK290575 BAF83264 AK297738 BAG60088 AK297937 BAG60253 AK299205 BAG61245 AK300984 BAG62604 AK313342 BAG36145 AY221101 AAO34406 BC002795 AAH02795 BC007231 AAH07231 BC013968 AAH13968 BC018636 AAH18636 BC095403 AAH95403 BT007060 AAP35709 BX641021 CAI46259 D01096 BAA00881 DA031108 DA549782 DQ893499 ABM84425 DQ896487 ABM87486 EU831423 ACE87110 EU831516 ACE86435 FM956488 CAX11668 M15518 AAA60111 M18182 AAA36800 M26666 V00570 CAA23833 X02901 X07393 CAA30302 X13097 CAA31489 NM_000930 NP_000921 NM_033011 NP_127509 NM_000931
Function	Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
Subcellular Location	Secreted, extracellular space.
Tissue Specificity	Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.
Top Pathways	Complement and coagulation cascades, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PAI1 + tPA Human ELISA - ab108892 from Abcam Prices $489.00 Sizes 1 x 96 tests Sensitivity = 0.06 ng/ml Range 0.063 ng/ml - 4 ng/ml

PAI1 (SERPINE1) - Tissue Plasminogen Activator (TPA) Complex Human SimpleStep ELISA™ Kit - ab192151 from Abcam Category ELISA Kit Prices $484.00 Sizes 1 x 96 tests Sensitivity 16 pg/ml Range 39 pg/ml - 2500 pg/ml

Tissue Plasminogen Activator (TPA) Human SimpleStep ELISA™ Kit - ab190812 from Abcam Category ELISA Kit Prices $484.00 Sizes 1 x 96 tests Sensitivity 3.5 pg/ml Range 78 pg/ml - 5000 pg/ml

Tissue Type Plasminogen Activator (TPA) Human ELISA Kit - ab108914 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity = 0.03 ng/ml Range 0.031 ng/ml - 2 ng/ml

Tissue type Plasminogen Activator Human ELISA Kit - ab119563 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity 6 pg/ml Range 15.6 pg/ml - 1000 pg/ml

Tissue type Plasminogen Activator Human Chromogenic Activity Assay Kit - ab108905 from Abcam Category Cellular Assay Prices $500.00 Sizes 100 tests Sensitivity 0.03 IU/ml Range 0.039 IU/ml - 40 IU/ml

Human PLAT / TPA ELISA Kit (Sandwich ELISA) - LS-F2742 from LifeSpan Bioscience Category ELISA Kit Prices $570.00 Sizes 1 plate Sensitivity 10 pg/ml Range 0.156-10 ng/ml

Human PLAT / TPA ELISA Kit (Sandwich ELISA) - LS-F5557 from LifeSpan Bioscience Category ELISA Kit Prices $580.00 Sizes 1 plate Sensitivity 0.059 ng/ml Range 0.156-10 ng/ml

Rat PLAT / TPA ELISA Kit (Sandwich ELISA) - LS-F5558 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.118 ng/ml Range 0.156-10 ng/ml

Mouse PLAT / TPA ELISA Kit (Sandwich ELISA) - LS-F5559 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Pig PLAT / TPA ELISA Kit (Sandwich ELISA) - LS-F5314 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.31 ng/ml Range 0.156-10 ng/ml

Human PLAT / TPA ELISA Kit (Direct ELISA) - LS-F10432 from LifeSpan Bioscience Category ELISA Kit Prices $570.00 Sizes 1 plate Sensitivity 0.0372 ng/ml Range 0.156-10 ng/ml

Mouse PLAT / TPA ELISA Kit (Sandwich ELISA) - LS-F10452 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.035 ng/ml Range 0.156-10 ng/ml

Rat PLAT / TPA ELISA Kit (Sandwich ELISA) - LS-F10463 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.042 ng/ml Range 0.156-10 ng/ml

Human PLAT / TPA ELISA Kit (Functional ELISA) - LS-F10467 from LifeSpan Bioscience Category ELISA Kit Prices $570.00 Sizes 1 plate Sensitivity 0.006 IU/ml Range 0.156-10 ng/ml

Pig PLAT / TPA ELISA Kit (Functional ELISA) - LS-F10473 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.018 ng/ml Range 0.156-10 ng/ml

Mouse PLAT / TPA ELISA Kit (Functional ELISA) - LS-F10470 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.014 ng/ml Range 0.156-10 ng/ml

Rat PLAT / TPA ELISA Kit (Functional ELISA) - LS-F10477 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.043 ng/ml Range 0.156-10 ng/ml

Rabbit PLAT / TPA ELISA Kit (Functional ELISA) - LS-F10475 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.181 ng/ml Range 0.156-10 ng/ml

Human PLAT / TPA ELISA Kit (Sandwich ELISA) - LS-F12832 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

t-Plasminogen Activator/tPA Colorimetric Assay Kit - KA0974 from Novus Biologicals Category Assay Kit Prices $659.00 Sizes 1 kit

PLAT/TPA BioAssay™ ELISA Kit, Human - 144012 from USBiological Life Science Category ELISA Kit Sensitivity < 10 pg/ml Range 31.2pg/ml-2000pg/ml

Quantikine Immunoassay Control Set 864 for Human tPA - QC207 from R&D Systems Category ELISA Kit Prices $125.00 Sizes 1 each

Human t-Plasminogen Activator/tPA Quantikine ELISA Kit - DTPA00 from R&D Systems Category ELISA Kit Prices $509.00 Sizes 1 kit Sensitivity 16.1 pg/mL Range 78.1 - 5,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma, Saliva, Urine, Human Milk)

Human tPA ELISA kit - 55R-IB49652 from Fitzgerald Category ELISA Kit Prices $765.00 Sizes 96 wells

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