PLAT

Gene Symbol PLAT
Entrez Gene 5327
Alt Symbol T-PA, TPA
Species Human
Gene Type protein-coding
Description plasminogen activator, tissue
Other Description alteplase|plasminogen activator, tissue type|reteplase|t-plasminogen activator|tissue plasminogen activator (t-PA)|tissue-type plasminogen activator
Swissprots A8K022 Q9BU99 Q86YK8 Q9BZW1 Q7Z7N2 B2R8E8 Q503B0 P00750 Q15103 Q6PJA5
Accessions AAA61213 AAA98809 AAB59510 AAP34246 CAA00166 CAA54669 CAJ18783 CAL48222 EAW63231 EAW63232 EAW63233 EAW63234 EAW63235 P00750 A03776 CAA00299 A07197 CAA00642 AF260825 AAK11956 AF282882 AAM52248 AK289387 BAF82076 AK290575 BAF83264 AK297738 BAG60088 AK297937 BAG60253 AK299205 BAG61245 AK300984 BAG62604 AK313342 BAG36145 AY221101 AAO34406 BC002795 AAH02795 BC007231 AAH07231 BC013968 AAH13968 BC018636 AAH18636 BC095403 AAH95403 BT007060 AAP35709 BX641021 CAI46259 D01096 BAA00881 DA031108 DA549782 DQ893499 ABM84425 DQ896487 ABM87486 EU831423 ACE87110 EU831516 ACE86435 FM956488 CAX11668 M15518 AAA60111 M18182 AAA36800 M26666 V00570 CAA23833 X02901 X07393 CAA30302 X13097 CAA31489 NM_000930 NP_000921 NM_033011 NP_127509 NM_000931
Function Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
Subcellular Location Secreted, extracellular space.
Tissue Specificity Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.
Top Pathways Complement and coagulation cascades, Transcriptional misregulation in cancer

tPA (C-16) - sc-5239 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
tPA (C-16): sc-5239. Western blot analysis of purified human tPA.

tPA (H-90) - sc-15346 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
tPA (H-90): sc-15346. Western blot analysis of purified human tPA.

tPA (N-14) - sc-5241 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
tPA (N-14): sc-5241. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing cytoplasmic staining of trophoblastic cells.

tPA (UK98/6) - sc-69740 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

tPA (2A153) - sc-59721 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Anti-TPA Tissue Plasminogen Activator antibody - ab14198 from Abcam

Host Goat
Clonality Polyclonal
a14198 staining TPA Tissue Plasminogen Activator (A - blue) in Rat hippocampal/thalamic region tissue sections by Immunohistochemistry (IHC-Fr - frozen sections). Tissue was fixed with paraformaldehyde. Tissue was incubated in pre-block solution (10% normal hourse serum in antibody diluent (PBS + 0.1% Trition X-100)) for 1 hour. Samples were incubated with primary antibody (1/50 in PBS + pre-block solution) for 16 hours. B - trypsin (red), C - PAR2 (green), D - merge.TPA Tissue Plasminogen Actvator and Trypsin co-localise.

Anti-TPA Tissue Plasminogen Activator antibody - ab140088 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human lung carcinoma tissue labelling TPA Tissue Plasminogen Activator with ab140088 at 1/100 dilution.

Anti-TPA Tissue Plasminogen Activator antibody - ab48649 from Abcam

Prices $370.00
Sizes 150 µg
Host Sheep
Clonality Polyclonal

Anti-TPA Tissue Plasminogen Activator antibody - ab28219 from Abcam

Prices $372.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TPA Tissue Plasminogen Activator antibody [2A153] - ab21049 from Abcam

Prices $381.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2A153

Anti-TPA Tissue Plasminogen Activator antibody [629.2A1.53] - ab27418 from Abcam

Prices $372.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone 629.2A1.53

Anti-TPA Tissue Plasminogen Activator antibody (Biotin) - ab51518 from Abcam

Prices $372.00
Sizes 150 µg
Host Sheep
Clonality Polyclonal

Anti-TPA Tissue Plasminogen Activator antibody [EPR7232(2)] - ab157469 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7232(2)
ab157469 showing +ve staining in Human normal liver.

Anti-TPA Tissue Plasminogen Activator antibody (FITC) - ab28376 from Abcam

Prices $370.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-TPA Tissue Plasminogen Activator antibody [T-1] - ab82249 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone T-1

Anti-PLAT / TPA Antibody (Biotin) - LS-C150945 from LifeSpan Bioscience

Prices $365.00
Sizes 1 mg
Host Sheep
Clonality Polyclonal

Anti-PLAT / TPA Antibody - LS-C150944 from LifeSpan Bioscience

Prices $315.00
Sizes 1 ml
Host Sheep
Clonality Polyclonal

Anti-PLAT / TPA Antibody (FITC) - LS-C150946 from LifeSpan Bioscience

Prices $365.00
Sizes 1 mg
Host Sheep
Clonality Polyclonal

Anti-PLAT / TPA Antibody - LS-C150958 from LifeSpan Bioscience

Prices $315.00
Sizes 1 ml
Host Sheep
Clonality Polyclonal

Anti-PLAT / TPA Antibody - LS-C150947 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-PLAT / TPA Antibody (Biotin) - LS-C150959 from LifeSpan Bioscience

Prices $365.00
Sizes 1 mg
Host Sheep
Clonality Polyclonal

Anti-PLAT / TPA Antibody (FITC) - LS-C150960 from LifeSpan Bioscience

Prices $365.00
Sizes 1 mg
Host Sheep
Clonality Polyclonal

Anti-PLAT / TPA Antibody - LS-C150961 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-PLAT / TPA Antibody - LS-C150971 from LifeSpan Bioscience

Prices $365.00
Sizes 1 ml
Host Sheep
Clonality Polyclonal

Anti-PLAT / TPA Antibody (Biotin) - LS-C150972 from LifeSpan Bioscience

Prices $405.00
Sizes 1 mg
Host Sheep
Clonality Polyclonal
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