PLAT

Gene Symbol PLAT
Entrez Gene 5327
Alt Symbol T-PA, TPA
Species Human
Gene Type protein-coding
Description plasminogen activator, tissue
Other Description alteplase|plasminogen activator, tissue type|reteplase|t-plasminogen activator|tissue plasminogen activator (t-PA)|tissue-type plasminogen activator
Swissprots A8K022 Q9BU99 Q86YK8 Q9BZW1 Q7Z7N2 B2R8E8 Q503B0 P00750 Q15103 Q6PJA5
Accessions AAA61213 AAA98809 AAB59510 AAP34246 CAA00166 CAA54669 CAJ18783 CAL48222 EAW63231 EAW63232 EAW63233 EAW63234 EAW63235 P00750 A03776 CAA00299 A07197 CAA00642 AF260825 AAK11956 AF282882 AAM52248 AK289387 BAF82076 AK290575 BAF83264 AK297738 BAG60088 AK297937 BAG60253 AK299205 BAG61245 AK300984 BAG62604 AK313342 BAG36145 AY221101 AAO34406 BC002795 AAH02795 BC007231 AAH07231 BC013968 AAH13968 BC018636 AAH18636 BC095403 AAH95403 BT007060 AAP35709 BX641021 CAI46259 D01096 BAA00881 DA031108 DA549782 DQ893499 ABM84425 DQ896487 ABM87486 EU831423 ACE87110 EU831516 ACE86435 FM956488 CAX11668 M15518 AAA60111 M18182 AAA36800 M26666 V00570 CAA23833 X02901 X07393 CAA30302 X13097 CAA31489 NM_000930 NP_000921 NM_033011 NP_127509 NM_000931
Function Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
Subcellular Location Secreted, extracellular space.
Tissue Specificity Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.
Top Pathways Complement and coagulation cascades, Transcriptional misregulation in cancer

tPA CRISPR/Cas9 KO Plasmid (h) - sc-400922 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

tPA HDR Plasmid (h) - sc-400922-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

tPA Double Nickase Plasmid (h) - sc-400922-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

tPA Double Nickase Plasmid (h2) - sc-400922-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

tPA CRISPR Activation Plasmid (h) - sc-400922-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

tPA CRISPR Activation Plasmid (h2) - sc-400922-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

tPA Lentiviral Activation Particles (h) - sc-400922-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

tPA Lentiviral Activation Particles (h2) - sc-400922-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

tPA siRNA (h) - sc-36705 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

tPA shRNA Plasmid (h) - sc-36705-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

tPA shRNA (h) Lentiviral Particles - sc-36705-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU069101 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16915 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16915 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08603 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08603

PLAT siRNA (Human) - CRH3567 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

tPA CRISPR/Cas9 KO Plasmid (h2) - sc-400922-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

tPA HDR Plasmid (h2) - sc-400922-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human PLAT (NM_000930.3) - SHH377036 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PLAT(NM_033011.2) - SHR119832 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PLAT(NM_000930.3) - SHR119842 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PLAT(NM_033011.2) - SHR119864 from Creative biogene

Category siRNA
Species Reactivities Human

Human PLAT siRNA - orb264069 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PLAT shRNA Plasmid (Human) - CHH3567 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PLAT miRNA 3'UTR clone - MiUTR1H-07974 from Creative biogene

Species Reactivities Human
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