Gene Symbol | ABCA3 |
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Entrez Gene | 21 |
Alt Symbol | ABC-C, ABC3, EST111653, LBM180, SMDP3 |
Species | Human |
Gene Type | protein-coding |
Description | ATP-binding cassette, sub-family A (ABC1), member 3 |
Other Description | ABC transporter 3|ABC-C transporter|ATP-binding cassette sub-family A member 3|ATP-binding cassette transporter 3 |
Swissprots | Q99758 Q92473 B2RU09 Q6P5P9 Q54A95 |
Accessions | AAY57325 EAW85515 Q99758 AB070929 BAB86781 AB210044 BAE06126 AK310864 BC020724 AAH20724 BC035752 BC062779 AAH62779 BC140895 AAI40896 BC146866 AAI46867 BC151840 AAI51841 BP397501 DA109409 U78735 AAC50967 X97187 CAA65825 NM_001089 NP_001080 |
Function | Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Highly expressed in lung, followed by brain, pancreas, skeletal muscle and heart. Weakly expressed in placenta, kidney and liver. Also expressed in medullary thyroid carcinoma cells (MTC) and in C-cell carcinoma. |
Top Pathways | ABC transporters |
ABCA3 CRISPR/Cas9 KO Plasmid (h) - sc-402388 from Santa Cruz Biotechnology
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ABCA3 HDR Plasmid (h) - sc-402388-HDR from Santa Cruz Biotechnology
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ABCA3 Double Nickase Plasmid (h) - sc-402388-NIC from Santa Cruz Biotechnology
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ABCA3 Double Nickase Plasmid (h2) - sc-402388-NIC-2 from Santa Cruz Biotechnology
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ABCA3 CRISPR Activation Plasmid (h) - sc-402388-ACT from Santa Cruz Biotechnology
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ABCA3 CRISPR Activation Plasmid (h2) - sc-402388-ACT-2 from Santa Cruz Biotechnology
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ABCA3 Lentiviral Activation Particles (h) - sc-402388-LAC from Santa Cruz Biotechnology
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ABCA3 Lentiviral Activation Particles (h2) - sc-402388-LAC-2 from Santa Cruz Biotechnology
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ABCA3 siRNA (h) - sc-60113 from Santa Cruz Biotechnology
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ABCA3 shRNA Plasmid (h) - sc-60113-SH from Santa Cruz Biotechnology
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ABCA3 shRNA (h) Lentiviral Particles - sc-60113-V from Santa Cruz Biotechnology
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ABCA3 RNAi - H00000021-R02 from Novus Biologicals
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MISSION® esiRNA - EHU157001 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1902 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1902 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06949 from Sigma-Aldrich
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ABCA3 siRNA (Human) - CRH0013 from Cohesion Biosciences
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ABCA3 - MBS8211308 from MyBioSource
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shRNA set against Human Abca3 (NM_001089.2) - SHH228850 from Creative biogene
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shRNA set against Human ABCA3(NM_001089.2) - SHG023039 from Creative biogene
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Human ABCA3 siRNA - orb260515 from Biorbyt
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ABCA3 shRNA Plasmid (Human) - CHH0013 from Cohesion Biosciences
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ABCA3 miRNA 3'UTR clone - MiUTR1H-00020 from Creative biogene
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