Gene Symbol |
ABCA3
|
Entrez Gene |
21
|
Alt Symbol |
ABC-C, ABC3, EST111653, LBM180, SMDP3
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
ATP-binding cassette, sub-family A (ABC1), member 3
|
Other Description |
ABC transporter 3|ABC-C transporter|ATP-binding cassette sub-family A member 3|ATP-binding cassette transporter 3
|
Swissprots |
Q99758 Q92473 B2RU09 Q6P5P9 Q54A95
|
Accessions |
AAY57325 EAW85515 Q99758 AB070929 BAB86781 AB210044 BAE06126 AK310864 BC020724 AAH20724 BC035752 BC062779 AAH62779 BC140895 AAI40896 BC146866 AAI46867 BC151840 AAI51841 BP397501 DA109409 U78735 AAC50967 X97187 CAA65825 NM_001089 NP_001080
|
Function |
Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol.
|
Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
Tissue Specificity |
Highly expressed in lung, followed by brain, pancreas, skeletal muscle and heart. Weakly expressed in placenta, kidney and liver. Also expressed in medullary thyroid carcinoma cells (MTC) and in C-cell carcinoma.
|
Top Pathways |
ABC transporters
|