SYNE3

Gene Symbol	SYNE3
Entrez Gene	161176
Alt Symbol	C14orf49, NET53, Nesp3
Species	Human
Gene Type	protein-coding
Description	spectrin repeat containing, nuclear envelope family member 3
Other Description	nesprin-3\|nuclear envelope spectrin repeat protein 3
Swissprots	Q6ZMZ3 Q8N7G8 Q86SX5 A6H8H3
Accessions	Q6ZMZ3 AK098471 BAC05312 AK131436 BAD18582 BC061899 AAH61899 BC146604 AAI46605 BM701154 BX248076 CAD62365 BX342493 BX346277 BX648302 XM_005267376 XP_005267433 XM_005267377 XP_005267434 XM_006720063 XP_006720126 XM_011536513 XP_011534815 XM_011536514 XP_011534816 XM_011536515 XP_011534817 XM_011536516 XP_011534818 NM_152592 NP_689805
Function	Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow- induced centrosome polarization and directional migration in aortic endothelial cells. {ECO:0000269\|PubMed:16330710, ECO:0000269\|PubMed:18396275, ECO:0000269\|PubMed:21937718}.
Subcellular Location	Nucleus outer membrane {ECO:0000269\|PubMed:21937718}; Single-pass type IV membrane protein {ECO:0000269\|PubMed:21937718}. Nucleus envelope {ECO:0000269\|PubMed:21937718}. Rough endoplasmic reticulum {ECO:0000250}.
Tissue Specificity	Expressed in aortic endothelial cells (at protein level). {ECO:0000269\|PubMed:21937718}.

Syne-3 (D-14) - sc-161402 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-Nesprin3 antibody - ab74261 from Abcam

Prices	$379.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Nesprin3 antibody (ab74261) at 1/500 dilutionLane 1 : Extracts from Jurkat cellsLane 2 : Extracts from Jurkat cells plus 5µg immunizing peptideLysates/proteins at 5 µg per lane.

Anti-Nesprin3 antibody - ab190010 from Abcam

Prices	$376.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Nesprin3 antibody (ab190010) at 1/500 dilutionLane 1 : Jurkat cell lysateLane 2 : Jurkat cell lysate with synthesized peptide

Anti-Nesprin3 antibody - ab107616 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-Nesprin3 antibody (ab107616) at 1/100 dilution + Mouse spleen cell line lysate at 35 µg

Anti-Nesprin3 antibody [EPR15623] - ab186746 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR15623

All lanes : Anti-Nesprin3 antibody [EPR15623] (ab186746) at 1/5000 dilutionLane 1 : Jurkat cell lysateLane 2 : 293 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-Nesprin3 antibody [EPR15623-5] - ab186751 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR15623-5

All lanes : Anti-Nesprin3 antibody [EPR15623-5] (ab186751) at 1/10000 dilutionLane 1 : Jurkat cell lysateLane 2 : 293 cell lysateLane 3 : HeLa cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-SYNE3 / C14orf49 Antibody (aa855-884, AP) - LS-C241449 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SYNE3 / C14orf49 Antibody (aa855-884, APC) - LS-C241450 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SYNE3 / C14orf49 Antibody (aa855-884, Biotin) - LS-C241451 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SYNE3 / C14orf49 Antibody (clone Nsp-3) - LS-C150518 from LifeSpan Bioscience

Prices	$285.00
Sizes	1 ml
Host	Mouse
Clonality	Monoclonal
Clone	Nsp-3

Immunofluorescence staining of a cultured mouse embryonic fibroblast with Nsp3 for nesprin-3a (green), and counter-staining of nuclear DNA with DAPI (blue).

Anti-SYNE3 / C14orf49 Antibody (aa855-884, FITC) - LS-C241452 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SYNE3 / C14orf49 Antibody (aa855-884, PE) - LS-C241453 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SYNE3 / C14orf49 Antibody (aa855-884) - LS-C330188 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SYNE3 / C14orf49 Antibody (aa855-884, Azide-free, HRP) - LS-C248291 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SYNE3 / C14orf49 Antibody (aa156-205) - LS-C201617 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of Human HepG2. SYNE3 antibody dilution 1.0 ug/ml.

Anti-SYNE3 / C14orf49 Antibody (aa169-218) IHC-plus™ - LS-B9849 from LifeSpan Bioscience

Prices	$395.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SYNE3 / C14orf49 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B9849 concentration 10 ug/ml.

Anti-SYNE3 / C14orf49 Antibody (aa855-884) - LS-C161640 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

SYNE3 antibody immunohistochemistry of formalin-fixed and paraffin-embedded human Hodgkin lymphoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Nesprin-3 Antibody - NBP1-71613 from Novus Biologicals

Prices	$229.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: Nesprin-3 Antibody [NBP1-71613] - Analysis of extracts from Jurkat cells, using Nesprin-3 Antibody. The lane on the right is treated with the synthesized peptide.

ANTI-SYNE3 (C-TERM) antibody produced in rabbit - SAB1303297 from Sigma-Aldrich

Prices	$326.50
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>SYNE3 (C-term): <B>Cat. No. SAB1303297</B>: SYNE3 in Human hodgkin lymphoma tissue with SYNE3 antibody (C-term) at 12.5 μg/mL.

Anti-C14ORF49 antibody produced in rabbit - SAB4500619 from Sigma-Aldrich

Prices	$335.50
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-C14ORF49: <B>Cat. No. SAB4500619</B>: Immunoblotting analysis of extracts from Jurkat cells, using Anti-C14ORF49 antibody. The lane on the left was treated with the Anti-C14ORF49 antibody. The lane on the right (negative control) was treated with both Anti-C14ORF49 antibody and the synthesized immunogen peptide.

SYNE3 Antibody - N-terminal region (ARP53053_P050) - ARP53053_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

C14orf49 Antibody - C-terminal region (OAAB00839) - OAAB00839 from Aviva Systems Biology

Prices	$289.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

SYNE3-Antibody-C-term - AP10823b from Abgent, a WuXi AppTec company

Prices	$99.00, $295.00
Sizes	80 µl, 400 µl
Host	Rabbit
Clonality	Polyclonal

SYNE3 Antibody (C-term) (Cat. #AP10823b) western blot analysis in mouse spleen cell line lysates (35ug/lane).This demonstrates the SYNE3 antibody detected the SYNE3 protein (arrow).

C14orf49-Antibody - AP50768 from Abgent, a WuXi AppTec company

Prices	$295.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of lysate from HepG2 cell line,using C14orf49 Antibody(AP50768). AP50768 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.

Nesprin 3 antibody - GTX87974 from GeneTex

Prices	$319.00
Sizes	100 μg
Host	Rabbit
Clonality	Polyclonal

Anti-C14orf49 antibody used in Western blot. GTX87974

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