SYNE3

Gene Symbol	SYNE3
Entrez Gene	161176
Alt Symbol	C14orf49, NET53, Nesp3
Species	Human
Gene Type	protein-coding
Description	spectrin repeat containing, nuclear envelope family member 3
Other Description	nesprin-3|nuclear envelope spectrin repeat protein 3
Swissprots	Q6ZMZ3 Q8N7G8 Q86SX5 A6H8H3
Accessions	Q6ZMZ3 AK098471 BAC05312 AK131436 BAD18582 BC061899 AAH61899 BC146604 AAI46605 BM701154 BX248076 CAD62365 BX342493 BX346277 BX648302 XM_005267376 XP_005267433 XM_005267377 XP_005267434 XM_006720063 XP_006720126 XM_011536513 XP_011534815 XM_011536514 XP_011534816 XM_011536515 XP_011534817 XM_011536516 XP_011534818 NM_152592 NP_689805
Function	Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow- induced centrosome polarization and directional migration in aortic endothelial cells. {ECO:0000269|PubMed:16330710, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:21937718}.
Subcellular Location	Nucleus outer membrane {ECO:0000269|PubMed:21937718}; Single-pass type IV membrane protein {ECO:0000269|PubMed:21937718}. Nucleus envelope {ECO:0000269|PubMed:21937718}. Rough endoplasmic reticulum {ECO:0000250}.
Tissue Specificity	Expressed in aortic endothelial cells (at protein level). {ECO:0000269|PubMed:21937718}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SYNE3 / C14orf49 Antibody Blocking Peptide - LS-E527 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SYNE3-Antibody-C-term-Blocking-peptide - BP10823b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SYNE3 Blocking Peptide - abx064075 from Abbexa Category Peptide Species Human, Mouse

Recombinant Human SYNE3 - SYNE3-1018H from Creative Biomart Category Protein Source Mammalian Cells Species Human

SYNE3 Blocking Peptide - CBP2881 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse

Recombinant Human Nesprin-3(C14orf49) ,partial - CSB-YP751151HU CSB-EP751151HU CSB-BP751151HU CSB-MP751151HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Nesprin-3 Recombinant Protein Antigen - NBP2-49175PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

SYNE3 Peptide, Human - M34GP15470H from Creative Peptides Category Peptide Source Synthetic. Species Human

C14orf49 protein (221-232) - ta-122 from Creative Peptides Category Protein Source Homo sapiens (human)

C14orf49 fusion protein - Ag26012 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Nesprin-3 Recombinant Protein Antigen - NBP2-57690PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Nesprin-3 (C14orf49), partial, Recombinant Protein - MBS1456709 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

C14orf49 fusion protein - Ag26002 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

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