Gene Symbol | CCL2 |
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Entrez Gene | 6347 |
Alt Symbol | GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF |
Species | Human |
Gene Type | protein-coding |
Description | chemokine (C-C motif) ligand 2 |
Other Description | C-C motif chemokine 2|monocyte chemoattractant protein 1|monocyte chemoattractant protein-1|monocyte chemotactic and activating factor|monocyte chemotactic protein 1|monocyte secretory protein JE|small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)|small inducible cytokine subfamily A (Cys-Cys), member 2|small-inducible cytokine A2 |
Swissprots | B2R4V3 Q9UDF3 P13500 |
Accessions | AAA18102 AAA36330 AAA60308 AAM54046 AAQ75526 BAA05080 CAC14049 EAW80211 EAW80212 P13500 AK311960 BAG34900 AV733621 BC009716 AAH09716 BG530064 BT007329 AAP35993 DQ893725 ABM84651 EU176175 ABW03626 M24545 AAA18164 M26683 AAA96708 M28226 AAA60309 S69738 AAB29926 X14768 CAA32876 NM_002982 NP_002973 |
Function | Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. |
Subcellular Location | Secreted. |
Top Pathways | Chagas disease (American trypanosomiasis), Malaria, Chemokine signaling pathway, Rheumatoid arthritis, NOD-like receptor signaling pathway |
MCP-1 CRISPR/Cas9 KO Plasmid (h) - sc-401046 from Santa Cruz Biotechnology
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MCP-1 HDR Plasmid (h) - sc-401046-HDR from Santa Cruz Biotechnology
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MCP-1 Double Nickase Plasmid (h) - sc-401046-NIC from Santa Cruz Biotechnology
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MCP-1 Double Nickase Plasmid (h2) - sc-401046-NIC-2 from Santa Cruz Biotechnology
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MCP-1 CRISPR Activation Plasmid (h) - sc-401046-ACT from Santa Cruz Biotechnology
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MCP-1 CRISPR Activation Plasmid (h2) - sc-401046-ACT-2 from Santa Cruz Biotechnology
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MCP-1 Lentiviral Activation Particles (h) - sc-401046-LAC from Santa Cruz Biotechnology
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MCP-1 Lentiviral Activation Particles (h2) - sc-401046-LAC-2 from Santa Cruz Biotechnology
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MCP-1 siRNA (h) - sc-43913 from Santa Cruz Biotechnology
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MCP-1 shRNA Plasmid (h) - sc-43913-SH from Santa Cruz Biotechnology
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MCP-1 shRNA (h) Lentiviral Particles - sc-43913-V from Santa Cruz Biotechnology
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CCL2/MCP1 RNAi - H00006347-R02 from Novus Biologicals
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MISSION® esiRNA - EHU021511 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5605 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5605 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03243 from Sigma-Aldrich
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CCL2 siRNA (Human) - CRH4282 from Cohesion Biosciences
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CCL2 - MBS8235134 from MyBioSource
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shRNA set against Human CCL2 (NM_002982.3) - SHH257549 from Creative biogene
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shRNA set against Human CCL2(NM_002982.3) - SHG150521 from Creative biogene
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Human MCP1 siRNA - orb264784 from Biorbyt
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CCL2 shRNA Plasmid (Human) - CHH4282 from Cohesion Biosciences
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CCL2 miRNA 3'UTR clone - MiUTR1H-01796 from Creative biogene
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