Gene Symbol | RBBP4 |
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Entrez Gene | 5928 |
Alt Symbol | NURF55, RBAP48, lin-53 |
Species | Human |
Gene Type | protein-coding |
Description | retinoblastoma binding protein 4 |
Other Description | CAF-1 subunit C|CAF-I 48 kDa subunit|CAF-I p48|MSI1 protein homolog|RBBP-4|chromatin assembly factor 1 subunit C|chromatin assembly factor I p48 subunit|chromatin assembly factor/CAF-1 p48 subunit|histone-binding protein RBBP4|nucleosome-remodeling factor subunit RBAP48|retinoblastoma-binding protein 4|retinoblastoma-binding protein p48 |
Swissprots | Q53H02 D3DPQ3 P31149 Q09028 Q96BV9 B4DRH0 B2R6G9 |
Accessions | CAH61602 EAX07513 EAX07514 EAX07515 Q09028 AK056356 AK056550 AK222779 BAD96499 AK299251 BAG61282 AK299410 BAG61392 AK312571 BAG35466 BC003092 AAH03092 BC015123 AAH15123 BC053904 AAH53904 BC075836 AAH75836 BT007309 AAP35973 DC315298 DQ892499 ABM83425 DQ895712 ABM86638 X71810 CAA50685 X74262 CAA52321 NM_001135255 NP_001128727 NM_001135256 NP_001128728 NM_005610 NP_005601 |
Function | Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654}. |
Subcellular Location | Nucleus. |
RbAp48 CRISPR/Cas9 KO Plasmid (h) - sc-403068 from Santa Cruz Biotechnology
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RbAp48 HDR Plasmid (h) - sc-403068-HDR from Santa Cruz Biotechnology
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RbAp48 Double Nickase Plasmid (h) - sc-403068-NIC from Santa Cruz Biotechnology
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RbAp48 Double Nickase Plasmid (h2) - sc-403068-NIC-2 from Santa Cruz Biotechnology
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RbAp48 CRISPR Activation Plasmid (h) - sc-403068-ACT from Santa Cruz Biotechnology
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RbAp48 CRISPR Activation Plasmid (h2) - sc-403068-ACT-2 from Santa Cruz Biotechnology
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RbAp48 Lentiviral Activation Particles (h) - sc-403068-LAC from Santa Cruz Biotechnology
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RbAp48 Lentiviral Activation Particles (h2) - sc-403068-LAC-2 from Santa Cruz Biotechnology
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RbAp48 siRNA (h) - sc-37962 from Santa Cruz Biotechnology
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RbAp48 shRNA Plasmid (h) - sc-37962-SH from Santa Cruz Biotechnology
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RbAp48 shRNA (h) Lentiviral Particles - sc-37962-V from Santa Cruz Biotechnology
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RBBP4/RbAp48 RNAi - H00005928-R01 from Novus Biologicals
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MISSION® esiRNA - EHU105811 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18010 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18010 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08201 from Sigma-Aldrich
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RBBP4 siRNA (Human) - CRH4014 from Cohesion Biosciences
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RBBP4 - MBS8221556 from MyBioSource
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shRNA set against Human RBBP4(NM_005610.2) - SHR167762 from Creative biogene
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Human RBBP4 siRNA - orb264516 from Biorbyt
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RBBP4 shRNA Plasmid (Human) - CHH4014 from Cohesion Biosciences
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RBBP4 miRNA 3'UTR clone - MiUTR1H-08665 from Creative biogene
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