| Gene Symbol |
RBBP4
|
| Entrez Gene |
5928
|
| Alt Symbol |
NURF55, RBAP48, lin-53
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
retinoblastoma binding protein 4
|
| Other Description |
CAF-1 subunit C|CAF-I 48 kDa subunit|CAF-I p48|MSI1 protein homolog|RBBP-4|chromatin assembly factor 1 subunit C|chromatin assembly factor I p48 subunit|chromatin assembly factor/CAF-1 p48 subunit|histone-binding protein RBBP4|nucleosome-remodeling factor subunit RBAP48|retinoblastoma-binding protein 4|retinoblastoma-binding protein p48
|
| Swissprots |
Q53H02 D3DPQ3 P31149 Q09028 Q96BV9 B4DRH0 B2R6G9
|
| Accessions |
CAH61602 EAX07513 EAX07514 EAX07515 Q09028 AK056356 AK056550 AK222779 BAD96499 AK299251 BAG61282 AK299410 BAG61392 AK312571 BAG35466 BC003092 AAH03092 BC015123 AAH15123 BC053904 AAH53904 BC075836 AAH75836 BT007309 AAP35973 DC315298 DQ892499 ABM83425 DQ895712 ABM86638 X71810 CAA50685 X74262 CAA52321 NM_001135255 NP_001128727 NM_001135256 NP_001128728 NM_005610 NP_005601
|
| Function |
Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654}.
|
| Subcellular Location |
Nucleus.
|
![Western Blot: RbAp48 Overexpression Lysate (Adult Normal) [NBL1-15185] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RbAp48.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7780_RbAp48%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15185-img0002.jpg)