SYNM

Gene Symbol	SYNM
Entrez Gene	23336
Alt Symbol	DMN, SYN
Species	Human
Gene Type	protein-coding
Description	synemin, intermediate filament protein
Other Description	desmuslin\|synemin\|synemin alpha\|synemin beta
Swissprots	Q8TE61 O15061 Q5NJJ9 Q8TE62 A7E2Y2 Q2TBJ4
Accessions	EAX02230 EAX02231 EAX02232 O15061 AB002351 BAA20810 AF359284 AAK57487 AJ310521 CAC83858 AJ310522 CAC83859 AJ697971 CAG27071 AK026420 AL833262 AW292788 BC022358 BC063699 BC110066 AAI10067 BC151243 AAI51244 DQ581412 NM_015286 NP_056101 NM_145728 NP_663780
Function	Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269\|PubMed:11353857, ECO:0000269\|PubMed:16777071, ECO:0000269\|PubMed:18028034}.
Subcellular Location	Cytoplasm, cytoskeleton. Cell junction, adherens junction. Note=There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z- lines, and another in which it interacts with both DTNA and DES at the costamere.
Tissue Specificity	Isoform 2 is strongly detected in adult heart, fetal skeletal muscles and fetal heart. Isoform 1 is weakly detected in fetal heart and also in fetal skeletal muscle. Isoform 1 and isoform 2 are detected in adult bladder (at protein level). The mRNA is predominantly expressed in heart and muscle with some expression in brain which may be due to tissue-specific isoforms. {ECO:0000269\|PubMed:11353857, ECO:0000269\|PubMed:11737198}.

Desmuslin (A-8) - sc-374484 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

Desmuslin (A-8): sc-374484. Western blot analysis of Desmuslin expression in human skeletal muscle (A) and human heart (B) tissue extracts.

Desmuslin (E-15) - sc-49649 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Desmuslin (H-300) - sc-99137 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Desmuslin (H-300): sc-99137. Western blot analysis of Desmuslin expression in human skeletal muscle tissue extract.

Desmuslin (S-16) - sc-49651 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Desmuslin (S-16): sc-49651. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skeletal muscle tissue showing cytoplasmic staining of myocytes.

Anti-Desmuslin antibody [M03] - ab89228 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	M03

Anti-Desmuslin antibody [M03] (ab89228) at 5 µg/ml + HeLa cell lysate at 50 µgdeveloped using the ECL technique

Anti-DMN / Desmuslin / Synemin Antibody (aa329-580, clone 5G1) - LS-C340000 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	5G1

IHC of paraffin-embedded Human bladder tissue using anti-SYNM mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-DMN / Desmuslin / Synemin Antibody (aa329-580, clone 7A9) - LS-C339998 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	7A9

IHC of paraffin-embedded Human prostate tissue using anti-SYNM mouse monoclonal antibody. (heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-DMN / Desmuslin / Synemin Antibody (aa329-580, clone 3D10) - LS-C340655 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3D10

IHC of paraffin-embedded Human tonsil using anti-SYNM mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-DMN / Desmuslin / Synemin Antibody (aa329-580, clone 2F4) - LS-C340045 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	2F4

IHC of paraffin-embedded Human endometrium tissue using anti-SYNM mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-DMN / Desmuslin / Synemin Antibody (aa329-580, clone 7H6) - LS-C339999 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	7H6

IHC of paraffin-embedded Human lymphoma tissue using anti-SYNM mouse monoclonal antibody. (heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

alpha Desmuslin Antibody - NBP2-37909 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry: alpha Desmuslin Antibody [NBP2-37909] - Staining of human heart muscle shows strong positivity in intercalated discs of myocytes.

alpha Desmuslin Antibody - NBP2-37892 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry: alpha Desmuslin Antibody [NBP2-37892] - Staining of human smooth muscle shows strong positivity in smooth muscle cells.

alpha Desmuslin Antibody (4G5) - H00023336-M03A from Novus Biologicals

Prices	$349.00
Sizes	200 µl
Host	Mouse
Clonality	Monoclonal
Clone	4G5

Western Blot: alpha Desmuslin Antibody (4G5) [H00023336-M03A] - DMN monoclonal antibody (M03), clone 4G5. Western Blot analysis of DMN expression in HeLa(Cat # L013V1 ).

alpha Desmuslin Antibody (4G5) - H00023336-M03 from Novus Biologicals

Prices	$359.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	4G5

Western Blot: alpha Desmuslin Antibody (4G5) [H00023336-M03] - DMN monoclonal antibody (M03), clone 4G5. Western Blot analysis of DMN expression in HeLa(Cat # L013V1 ).

Desmuslin Polyclonal Antibody - bs-8555R from Bioss

Prices	$279.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Formalin-fixed and paraffin embedded rat heart labeled with Rabbit Anti Desmuslin Polyclonal Antibody, Unconjugated (bs-8555R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-Synemin (N-terminal) antibody produced in rabbit - S9075 from Sigma-Aldrich

Prices	$61.10, $360.00
Sizes	25 µl, 200 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Cytoplasmic localization of synemin in human skeletal muscle (endothelial cells in tissue vasculature). Fixed tissue was stained with Anti-Synemin (N-terminal) (antibody dilution 1:100) (<B>Cat. No. S9075</B>) followed by Goat Anti-Rabbit IgG, Cy3 conjugate (×40 magnification). Nuclear staining with DAPI.

Monoclonal Anti-DMN antibody produced in mouse - WH0023336M3 from Sigma-Aldrich

Prices	$347.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	4G5

Anti-Synemin antibody produced in rabbit - S8950 from Sigma-Aldrich

Prices	$61.10, $360.00
Sizes	25 µl, 200 µl
Host	Rabbit
Clonality	Polyclonal

$Immunoblotting Tissue lysate was separated on SDS-PAGE, blotted with 1.5 μg/mL Anti-Synemin (Cat. No. S8950) and developed using Goat Anti-Rabbit IgG-Peroxidase (Cat. No. A0545) and a chemiluminescent substrate. Lanes 1. Rat brain (S1 fraction) 2. Rat brain (S1 fraction). Antibody+Synemin immunizing peptide (human, 523-538)$

Monoclonal Anti-DMN, (C-terminal) antibody produced in mouse - SAB1404966 from Sigma-Aldrich

Prices	$347.00
Sizes	200 µl
Host	Mouse
Clonality	Monoclonal
Clone	4G5

<B>Immunoblotting</B><BR/>Monoclonal Anti-DMN: <B>Cat. No. SAB1404966</B>: Antibody concentration: 1 μg/mL. Specific band of ~37.1 kDa using immunogen protein lysate.

Synapsin antibody - 70R-12465 from Fitzgerald

Prices	$365.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Synemin / SYNM antibody - 20735-1-AP from Acris Antibodies

Prices	$270.00
Sizes	150 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical of paraffin-embedded human heart using 20735-1-AP(SYNM antibody) at dilution of 1:50 (under 10x lens)

Synemin / SYNM antibody - H00023336-M03 from Acris Antibodies

Prices	$360.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	4G5

DMN monoclonal antibody (M03), clone 4G5. Western Blot analysis of DMN expression in HeLa(Cat # L013V1 ).

Synemin / SYNM antibody - H00023336-M03A from Acris Antibodies

Prices	$360.00
Sizes	200 µl
Host	Mouse
Clonality	Monoclonal
Clone	4G5

SYNM antibody - 20735-1-AP from Proteintech Group

Prices	$279.00
Sizes	con: 48 μg/150μl
Host	Rabbit
Clonality	Polyclonal

Y79 cells were subjected to SDS PAGE followed by western blot with 20735-1-AP(SYNM antibody) at dilution of 1:1000

SYNM, Monoclonal Antibody - MBS642834 from MyBioSource

Prices	$580.00
Sizes	200 µl
Host	Mouse
Clonality	Monoclonal
Clone	4G5

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