| Gene Symbol | SYNM |
|---|---|
| Entrez Gene | 23336 |
| Alt Symbol | DMN, SYN |
| Species | Human |
| Gene Type | protein-coding |
| Description | synemin, intermediate filament protein |
| Other Description | desmuslin|synemin|synemin alpha|synemin beta |
| Swissprots | Q8TE61 O15061 Q5NJJ9 Q8TE62 A7E2Y2 Q2TBJ4 |
| Accessions | EAX02230 EAX02231 EAX02232 O15061 AB002351 BAA20810 AF359284 AAK57487 AJ310521 CAC83858 AJ310522 CAC83859 AJ697971 CAG27071 AK026420 AL833262 AW292788 BC022358 BC063699 BC110066 AAI10067 BC151243 AAI51244 DQ581412 NM_015286 NP_056101 NM_145728 NP_663780 |
| Function | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| Subcellular Location | Cytoplasm, cytoskeleton. Cell junction, adherens junction. Note=There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z- lines, and another in which it interacts with both DTNA and DES at the costamere. |
| Tissue Specificity | Isoform 2 is strongly detected in adult heart, fetal skeletal muscles and fetal heart. Isoform 1 is weakly detected in fetal heart and also in fetal skeletal muscle. Isoform 1 and isoform 2 are detected in adult bladder (at protein level). The mRNA is predominantly expressed in heart and muscle with some expression in brain which may be due to tissue-specific isoforms. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:11737198}. |
Desmuslin CRISPR/Cas9 KO Plasmid (h) - sc-409241 from Santa Cruz Biotechnology
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Desmuslin HDR Plasmid (h) - sc-409241-HDR from Santa Cruz Biotechnology
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Desmuslin Double Nickase Plasmid (h) - sc-409241-NIC from Santa Cruz Biotechnology
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Desmuslin Double Nickase Plasmid (h2) - sc-409241-NIC-2 from Santa Cruz Biotechnology
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Desmuslin CRISPR Activation Plasmid (h) - sc-409241-ACT from Santa Cruz Biotechnology
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Desmuslin CRISPR Activation Plasmid (h2) - sc-409241-ACT-2 from Santa Cruz Biotechnology
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Desmuslin Lentiviral Activation Particles (h) - sc-409241-LAC from Santa Cruz Biotechnology
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Desmuslin Lentiviral Activation Particles (h2) - sc-409241-LAC-2 from Santa Cruz Biotechnology
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Desmuslin siRNA (h) - sc-60525 from Santa Cruz Biotechnology
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Desmuslin shRNA Plasmid (h) - sc-60525-SH from Santa Cruz Biotechnology
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Desmuslin shRNA (h) Lentiviral Particles - sc-60525-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU079201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20901 from Sigma-Aldrich
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SYNM siRNA (Human) - CRH8191 from Cohesion Biosciences
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SYNM - MBS8233031 from MyBioSource
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shRNA set against Human SYNM (NM_015286.5) - SHH421792 from Creative biogene
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SYNM shRNA Plasmid (Human) - CHH8191 from Cohesion Biosciences
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SYNM miRNA 3'UTR clone - MiUTR1H-02885 from Creative biogene
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SYNM miRNA 3'UTR clone - MiUTR4H-TG08705 from Creative biogene
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