SYNM

Gene Symbol	SYNM
Entrez Gene	23336
Alt Symbol	DMN, SYN
Species	Human
Gene Type	protein-coding
Description	synemin, intermediate filament protein
Other Description	desmuslin|synemin|synemin alpha|synemin beta
Swissprots	Q8TE61 O15061 Q5NJJ9 Q8TE62 A7E2Y2 Q2TBJ4
Accessions	EAX02230 EAX02231 EAX02232 O15061 AB002351 BAA20810 AF359284 AAK57487 AJ310521 CAC83858 AJ310522 CAC83859 AJ697971 CAG27071 AK026420 AL833262 AW292788 BC022358 BC063699 BC110066 AAI10067 BC151243 AAI51244 DQ581412 NM_015286 NP_056101 NM_145728 NP_663780
Function	Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}.
Subcellular Location	Cytoplasm, cytoskeleton. Cell junction, adherens junction. Note=There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z- lines, and another in which it interacts with both DTNA and DES at the costamere.
Tissue Specificity	Isoform 2 is strongly detected in adult heart, fetal skeletal muscles and fetal heart. Isoform 1 is weakly detected in fetal heart and also in fetal skeletal muscle. Isoform 1 and isoform 2 are detected in adult bladder (at protein level). The mRNA is predominantly expressed in heart and muscle with some expression in brain which may be due to tissue-specific isoforms. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:11737198}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Desmuslin protein fragment - ab161606 from Abcam Category Protein Source Wheat germ Species Human

SYN / FYN Antibody Blocking Peptide - LS-E3641 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SYN / FYN Antibody Blocking Peptide - LS-E25239 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SYN / FYN Antibody Blocking Peptide - LS-E9210 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SYN / FYN Antibody Blocking Peptide - LS-E9211 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SYN / FYN Antibody Blocking Peptide - LS-E20089 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SYN / FYN Antibody Blocking Peptide - LS-E20090 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human alpha Desmuslin Protein - H00023336-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Synemin / SYNM - H00023336-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Synemin / SYNM - H00023336-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Recombinant Methanothermobacter thermautotrophicus Acetyl-CoA decarbonylase/syn - CSB-YP523012MSR CSB-EP523012MSR CSB-BP523012MSR CSB-MP523012MSR from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Methanothermobacter

Recombinant Methanothermobacter thermautotrophicus Acetyl-CoA decarbonylase/syn - CSB-YP521473MSR CSB-EP521473MSR CSB-BP521473MSR CSB-MP521473MSR from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Methanothermobacter

Recombinant Methanothermobacter thermautotrophicus Acetyl-CoA decarbonylase/syn - CSB-YP519743MSR CSB-EP519743MSR CSB-BP519743MSR CSB-MP519743MSR from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Methanothermobacter

Recombinant Human Synemin(SYNM) ,partial - CSB-YP023019HU CSB-EP023019HU CSB-BP023019HU CSB-MP023019HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

alpha Desmuslin Protein - NBP2-37909PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

alpha Desmuslin Recombinant Protein Antigen - NBP2-37892PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SYNM Peptide, Human - M34GP15481H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human Tyrosine-Protein Kinasefyn/Syn - 230-00785-10 from RayBiotech Category Protein Prices $79.53 Sizes 10 µg Source Escherichia coli (E.coli) Species Human

Human Syn protein - orb385099 from Biorbyt Category Protein Prices $374.00, $391.00 Sizes 10 μg, 50 μg Species Human

alpha Desmuslin Recombinant Protein Antigen - NBP2-58028PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Synemin (SYNM), partial, Recombinant Protein - MBS1231325 from MyBioSource Category Protein Prices $1,115.00, $1,115.00, $1,345.00, $1,345.00, $1,715.00, $1,715.00, $2,175.00, $2,175.00, $2,205.00, $3,380.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Human Syn, transfected HEK293 cell Lysate - orb385132 from Biorbyt Category Protein Species Human

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