CD274

Gene Symbol	CD274
Entrez Gene	29126
Alt Symbol	B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1
Species	Human
Gene Type	protein-coding
Description	CD274 molecule
Other Description	B7 homolog 1|CD274 antigen|PDCD1 ligand 1|programmed cell death 1 ligand 1|programmed death ligand 1
Swissprots	Q9NUZ5 Q6WEX4 B4DU27 Q14CJ2 Q2V8D5 Q9NZQ7 Q66RK1 B2RBA2
Accessions	CCF77002 EAW58763 Q9NZQ7 AF177937 AAF25807 AF233516 AAG18508 AI826502 AK001894 BAA91966 AK300470 BAG62189 AK314567 BAG37149 AY254342 AAP13470 AY291313 AAP42144 AY714881 AAU09634 BC069381 AAH69381 BC074984 AAH74984 BC113734 AAI13735 BC113736 AAI13737 DQ286582 ABB90152 DQ836393 ABI16084 HQ258151 ADR82905 XM_006716759 XP_006716822 NM_001267706 NP_001254635 NM_014143 NP_054862 NR_052005
Function	Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443}.
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443}.
Top Pathways	Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PD-L1 protein fragment - ab167713 from Abcam Category Protein Prices $352.00 Sizes 100 µg Source HEK 293 cells Species Human

Active human PD-L1 protein fragment - ab182689 from Abcam Category Protein Prices $400.00 Sizes 25 µg Source HEK 293 cells Species Human

Active mouse PD-L1 protein fragment - ab180058 from Abcam Category Protein Prices $385.00 Sizes 200 µg Source HEK 293 cells Species Mouse

Human PD-L1 peptide - ab45676 from Abcam Category Peptide Species Human

Human PD-L1 protein fragment - ab112410 from Abcam Category Protein Source Wheat germ Species Human

Human PD-L1 protein fragment - ab126688 from Abcam Category Protein Source E. coli Species Human

Human PD-L1 protein fragment - ab134858 from Abcam Category Protein Source E. coli Species Human

Human PD-L1 protein fragment - ab151390 from Abcam Category Protein Source HEK 293 cells Species Human

Mouse PD-L1 protein fragment - ab130039 from Abcam Category Protein Source E. coli Species Mouse

PD-L1 peptide - ab184846 from Abcam Category Peptide

B7-H1 / PD-L1 / CD274 Antibody Blocking Peptide - LS-E3496 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

B7-H1 / PD-L1 / CD274 Antibody Blocking Peptide - LS-E30319 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

B7-H1/PD-L1/CD274 Partial Recombinant Protein - H00029126-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PD-L1/B7-H1 Blocking Peptide - NBP1-76769PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Recombinant Human B7-H1/PD-L1/CD274 Protein - NBP1-98984 from Novus Biologicals Category Protein Prices $269.00 Sizes 20 µg Source E. coli Species Human

Recombinant Mouse PD-L1/B7-H1 Protein - NBP1-98887 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E.coli

B7-H1/PD-L1/CD274 Recombinant Protein - P4938 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 25 µg Species Human

B7-H1/PD-L1/CD274 Recombinant Protein - H00029126-G01-10ug from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

CD274-Antibody-C-term-Blocking-Peptide - BP14682b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PD-L1 antibody blocking peptide - GTX89590-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant Human B7-H1 Fc Chimera, CF - 156-B7-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human B7H1 Fc tag protein - orb82868 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 100 μg, 200 μg Source Human Species Human

Mouse CD274 protein - orb168071 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Mouse

Human B7H1 His tag protein - orb83250 from Biorbyt Category Protein Prices $400.00, $595.00 Sizes 50 μg, 100 μg Source Human Species Human

Canine CD274 (Fc Tag) protein - orb179726 from Biorbyt Category Protein Prices $434.00, $612.00 Sizes 100 μg, 200 μg Source Human Cells

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