CD274

Gene Symbol	CD274
Entrez Gene	29126
Alt Symbol	B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1
Species	Human
Gene Type	protein-coding
Description	CD274 molecule
Other Description	B7 homolog 1|CD274 antigen|PDCD1 ligand 1|programmed cell death 1 ligand 1|programmed death ligand 1
Swissprots	Q9NUZ5 Q6WEX4 B4DU27 Q14CJ2 Q2V8D5 Q9NZQ7 Q66RK1 B2RBA2
Accessions	CCF77002 EAW58763 Q9NZQ7 AF177937 AAF25807 AF233516 AAG18508 AI826502 AK001894 BAA91966 AK300470 BAG62189 AK314567 BAG37149 AY254342 AAP13470 AY291313 AAP42144 AY714881 AAU09634 BC069381 AAH69381 BC074984 AAH74984 BC113734 AAI13735 BC113736 AAI13737 DQ286582 ABB90152 DQ836393 ABI16084 HQ258151 ADR82905 XM_006716759 XP_006716822 NM_001267706 NP_001254635 NM_014143 NP_054862 NR_052005
Function	Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443}.
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443}.
Top Pathways	Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human B7H1 gene - orb90701 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Mouse PD-L1/B7-H1 (NP_068693) VersaClone cDNA - RDC0752 from R&D Systems Prices $199.00 Sizes 10 µg Species Mouse

Human PD-L1/B7-H1 (NP_054862) VersaClone cDNA - RDC1087 from R&D Systems Prices $199.00 Sizes 10 µg Species Human

CD274 - MBS1278267 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC113734

Human PD-L1/B7-H1/CD274 Gene ORF cDNA clone in cloning vector - HG10084-M from Sino Biological Species Human

Human PD-L1/B7-H1/CD274 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10084-CY from Sino Biological Species Human

Human PD-L1/B7-H1/CD274 Gene ORF cDNA clone expression plasmid - HG10084-UT from Sino Biological Species Human

Human PD-L1/B7-H1/CD274 Gene ORF cDNA clone expression plasmid, C-His tag - HG10084-CH from Sino Biological Species Human

Human PD-L1/B7-H1/CD274 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10084-NY from Sino Biological Species Human

Human PD-L1/B7-H1/CD274 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10084-NF from Sino Biological Species Human

Human PD-L1/B7-H1/CD274 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10084-CF from Sino Biological Species Human

Human PD-L1/B7-H1/CD274 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10084-ACG from Sino Biological Species Human

Human PD-L1/B7-H1/CD274 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10084-NM from Sino Biological Species Human

Human PD-L1/B7-H1/CD274 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10084-CM from Sino Biological Species Human

Human PD-L1/B7-H1/CD274 Gene ORF cDNA clone expression plasmid, N-His tag - HG10084-NH from Sino Biological Species Human

B7-H1/PD-L1 - CL01195H01 from Elabscience Species Human Accession NM_001267706.1

B7-H1/PD-L1 - CL01195H02 from Elabscience Species Human Accession NM_014143.3

Cynomolgus Monkey PD-L1/B7-H1 (XP_005581836) VersaClone cDNA - RDC1288 from R&D Systems Prices $199.00 Sizes 10 µg Species Monkey

Human CD274 ORF clone (NM_001267706.1) - CDCR044120 from Creative biogene Species Human

Human CD274 ORF Clone (BC113734) - CDCS413501 from Creative biogene Species Human Accession Q9NZQ7

Human PD-L1/B7-H1/CD274 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10084-ACR from Sino Biological Species Human

Rat PD-L1/B7-H1 (NP_001178883) VersaClone cDNA - RDC1904 from R&D Systems Prices $199.00 Sizes 10 µg Species Rat

Canine PD-L1/B7-H1 (NP_001278901) VersaClone cDNA - RDC2007 from R&D Systems Prices $199.00 Sizes 10 µg Species Dog

Search more