CD274

Gene Symbol	CD274
Entrez Gene	29126
Alt Symbol	B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1
Species	Human
Gene Type	protein-coding
Description	CD274 molecule
Other Description	B7 homolog 1|CD274 antigen|PDCD1 ligand 1|programmed cell death 1 ligand 1|programmed death ligand 1
Swissprots	Q9NUZ5 Q6WEX4 B4DU27 Q14CJ2 Q2V8D5 Q9NZQ7 Q66RK1 B2RBA2
Accessions	CCF77002 EAW58763 Q9NZQ7 AF177937 AAF25807 AF233516 AAG18508 AI826502 AK001894 BAA91966 AK300470 BAG62189 AK314567 BAG37149 AY254342 AAP13470 AY291313 AAP42144 AY714881 AAU09634 BC069381 AAH69381 BC074984 AAH74984 BC113734 AAI13735 BC113736 AAI13737 DQ286582 ABB90152 DQ836393 ABI16084 HQ258151 ADR82905 XM_006716759 XP_006716822 NM_001267706 NP_001254635 NM_014143 NP_054862 NR_052005
Function	Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443}.
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443}.
Top Pathways	Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Total PD-L1 Sandwich ELISA Kit - 14784 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

Mouse CD274 / B7-H1 / PD-L1 ELISA Kit (Sandwich ELISA) - LS-F7665 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.312-20 ng/ml

Mouse CD274 / B7-H1 / PD-L1 ELISA Kit (Sandwich ELISA) - LS-F12278 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.312-20 ng/ml

Human CD274 / B7-H1 / PD-L1 ELISA Kit (Sandwich ELISA) - LS-F6475 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.312 ng/ml Range 0.312-20 ng/ml

Human CD274 / B7-H1 / PD-L1 ELISA Kit (Sandwich ELISA) - LS-F12277 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 ng/ml Range 0.312-20 ng/ml

Human PD-L1/B7-H1 DuoSet ELISA - DY156 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 156.25 - 10,000 pg/mL

Human PDCD1LG1 ELISA Kit - abx152667 from Abbexa Category ELISA Kit Sensitivity 0.056 ng/ml Range 0.156 ng/ml - 10 ng/ml

Programmed Cell Death Protein 1 Ligand 1, PDCD1LG1, Human, ELISA Kit - E-EL-H1547 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Programed Death Ligand-1, PDL1/B7-H1/CD274, Human, ELISA Kit - YHB2446Hu from ARP American Research Products Category ELISA Kit

Programmed cell death 1 ligand 1, CD274, Human, ELISA Kit - E0513h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Programmed cell death 1 ligand 1, Human, ELISA Kit - E01P0181 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Programmed Cell Death Protein 1 Ligand 1 (PDCD1LG1), Human, ELISA Kit - SEA788Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.051ng/mL Range 0.156-10ng/mL

Programmed Death Ligand-1 (PD-L1/CD274), Human, ELISA Kit - CSB-E13644h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

CD274 (Human) Matched Antibody Pair - H00029126-AP41 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human PD-L1 ELISA Kit - KE00074 from Proteintech Group Category ELISA Kit Prices $599.00 Sizes 1 Sensitivity 0.04 ng/mL Range 0.156 ng/mL-10 ng/mL

PDCD1LG1, ELISA Kit - MBS2502733 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Human PDCD1LG1 is 0.094ng/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 0.156-10ng/mL

PDCD1LG1, ELISA Kit - MBS2516306 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 46.875pg/mL Range 78.125-5000pg/mL

Programmed cell death 1 ligand 1, ELISA Kit - MBS750081 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Programmed cell death 1 ligand 1, ELISA Kit - MBS744712 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Programmed cell death 1 ligand 1, ELISA Kit - MBS752680 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Programmed cell death 1 ligand 1, ELISA Kit - MBS744767 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Programmed cell death 1 ligand 1, ELISA Kit - MBS747108 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Programmed cell death 1 ligand 1, ELISA Kit - MBS744572 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Programmed cell death 1 ligand 1, ELISA Kit - MBS745856 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Programmed cell death 1 ligand 1, ELISA Kit - MBS747146 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL

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