SLC1A1

Gene Symbol SLC1A1
Entrez Gene 6505
Alt Symbol DCBXA, EAAC1, EAAT3, SCZD18
Species Human
Gene Type protein-coding
Description solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Other Description excitatory amino acid carrier 1|excitatory amino acid transporter 3|neuronal and epithelial glutamate transporter|sodium-dependent glutamate/aspartate transporter 3|solute carrier family 1 member 1
Swissprots Q9UEW2 Q8N199 O75587 Q5VZ24 P43005
Accessions AAC27511 EAW58786 P43005 AB008536 BAB83767 AF037982 AAC25029 AK313013 BAG35848 BC033040 AAH33040 BQ008494 BQ029108 CB984615 CK903716 DA643262 DQ892425 ABM83351 DQ895639 ABM86565 U03506 AAA50430 U06469 AAA53215 U08989 AAA68628 XM_011518007 XP_011516309 XM_011518008 XP_011516310 XM_011518009 XP_011516311 XM_011518010 XP_011516312 NM_004170 NP_004161
Function Transports L-glutamate, L- and D-aspartate and L-cystein (PubMed:21123949). Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity). {ECO:0000250|UniProtKB:P51906, ECO:0000250|UniProtKB:P51907, ECO:0000269|PubMed:21123949}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:21123949}; Multi-pass membrane protein. Apical cell membrane {ECO:0000269|PubMed:21123949}; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Tissue Specificity Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers). {ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:7859077, ECO:0000269|PubMed:7914198}.
Top Pathways Protein digestion and absorption, Glutamatergic synapse

EAAT3 CRISPR/Cas9 KO Plasmid (h) - sc-401539 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EAAT3 HDR Plasmid (h) - sc-401539-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EAAT3 Double Nickase Plasmid (h) - sc-401539-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EAAT3 Double Nickase Plasmid (h2) - sc-401539-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EAAT3 CRISPR Activation Plasmid (h) - sc-401539-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EAAT3 CRISPR Activation Plasmid (h2) - sc-401539-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EAAT3 Lentiviral Activation Particles (h) - sc-401539-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EAAT3 Lentiviral Activation Particles (h2) - sc-401539-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EAAT3 siRNA (h) - sc-41940 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EAAT3 shRNA Plasmid (h) - sc-41940-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EAAT3 shRNA (h) Lentiviral Particles - sc-41940-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EAAT3 RNAi - H00006505-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU039711 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19445 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19445 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SLC1A1 siRNA (Human) - CRH4400 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC1A1 - MBS8240883 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SLC1A1 (NM_004170.5) - SHH408896 from Creative biogene

Category siRNA
Species Reactivities Human

SLC1A1 shRNA Plasmid (Human) - CHH4400 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SLC1A1 miRNA 3'UTR clone - MiUTR3H-00768 from Creative biogene

Species Reactivities Human
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