| Gene Symbol |
SLC1A1
|
| Entrez Gene |
6505
|
| Alt Symbol |
DCBXA, EAAC1, EAAT3, SCZD18
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
|
| Other Description |
excitatory amino acid carrier 1|excitatory amino acid transporter 3|neuronal and epithelial glutamate transporter|sodium-dependent glutamate/aspartate transporter 3|solute carrier family 1 member 1
|
| Swissprots |
Q9UEW2 Q8N199 O75587 Q5VZ24 P43005
|
| Accessions |
AAC27511 EAW58786 P43005 AB008536 BAB83767 AF037982 AAC25029 AK313013 BAG35848 BC033040 AAH33040 BQ008494 BQ029108 CB984615 CK903716 DA643262 DQ892425 ABM83351 DQ895639 ABM86565 U03506 AAA50430 U06469 AAA53215 U08989 AAA68628 XM_011518007 XP_011516309 XM_011518008 XP_011516310 XM_011518009 XP_011516311 XM_011518010 XP_011516312 NM_004170 NP_004161
|
| Function |
Transports L-glutamate, L- and D-aspartate and L-cystein (PubMed:21123949). Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity). {ECO:0000250|UniProtKB:P51906, ECO:0000250|UniProtKB:P51907, ECO:0000269|PubMed:21123949}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:21123949}; Multi-pass membrane protein. Apical cell membrane {ECO:0000269|PubMed:21123949}; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers). {ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:7859077, ECO:0000269|PubMed:7914198}.
|
| Top Pathways |
Protein digestion and absorption, Glutamatergic synapse
|
![Western Blot: EAAT3 Overexpression Lysate (Adult Normal) [NBP2-04266] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for EAAT3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/22920_EAAT3%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-04266-img0001.jpg)