SLC1A1

Gene Symbol	SLC1A1
Entrez Gene	6505
Alt Symbol	DCBXA, EAAC1, EAAT3, SCZD18
Species	Human
Gene Type	protein-coding
Description	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Other Description	excitatory amino acid carrier 1|excitatory amino acid transporter 3|neuronal and epithelial glutamate transporter|sodium-dependent glutamate/aspartate transporter 3|solute carrier family 1 member 1
Swissprots	Q9UEW2 Q8N199 O75587 Q5VZ24 P43005
Accessions	AAC27511 EAW58786 P43005 AB008536 BAB83767 AF037982 AAC25029 AK313013 BAG35848 BC033040 AAH33040 BQ008494 BQ029108 CB984615 CK903716 DA643262 DQ892425 ABM83351 DQ895639 ABM86565 U03506 AAA50430 U06469 AAA53215 U08989 AAA68628 XM_011518007 XP_011516309 XM_011518008 XP_011516310 XM_011518009 XP_011516311 XM_011518010 XP_011516312 NM_004170 NP_004161
Function	Transports L-glutamate, L- and D-aspartate and L-cystein (PubMed:21123949). Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity). {ECO:0000250|UniProtKB:P51906, ECO:0000250|UniProtKB:P51907, ECO:0000269|PubMed:21123949}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:21123949}; Multi-pass membrane protein. Apical cell membrane {ECO:0000269|PubMed:21123949}; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Tissue Specificity	Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers). {ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:7859077, ECO:0000269|PubMed:7914198}.
Top Pathways	Protein digestion and absorption, Glutamatergic synapse

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EAAT3 full length protein - ab132484 from Abcam Category Protein Source Wheat germ Species Human

Human EAAT3 peptide - ab48052 from Abcam Category Peptide Species Human

Rat EAAT3 peptide - ab42324 from Abcam Category Peptide

SLC1A1 / EAAT3 Antibody Blocking Peptide - LS-E16127 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SLC1A1 / EAAT3 Antibody Blocking Peptide - LS-E16128 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EAAT3 Recombinant Protein - H00006505-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SLC1A1 peptide - orb217933 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse

SLC1A1 Blocking Peptide - 33R-9692 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SLC1A1 Blocking Peptide - 33R-4852 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EAAT3 Blocking Peptide - abx063264 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

SLC1A1 - H00006505-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SLC1A1 - H00006505-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SLC1A1 fusion protein - Ag3379 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human SLC1A1, GST-tagged - SLC1A1-2703H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Excitatory Amino Acid Transporter 3 (EAAT3) - RPE342Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

EAAT3 Blocking Peptide - CBP2070 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

EAAT3 (P171) Peptide - BS2875P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Excitatory Amino Acid Transporter 3 (EAAT3) - RPE342Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Excitatory Amino Acid Transporter 3 Protein (Recombinant) - abx167099 from Abbexa Category Protein Source Human Species Human

Recombinant Homo sapiens (Human) xcitatory amino acid transporter 3 - CSB-EP021432HU from Cusabio Category Protein Source E.coli Species Human

EAAT3 Recombinant Protein Antigen - NBP1-84938PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SLC1A1 Peptide, Human - M34GP14364H from Creative Peptides Category Peptide Source Synthetic. Species Human

SLC1A1 Recombinant Protein (OPCA03202) - OPCA03202 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Human SLC1A1 protein - orb358432 from Biorbyt Category Protein Prices $221.00, $366.00, $646.00, $1,071.00, $1,692.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

Recombinant Excitatory Amino Acid Transporter 3 (EAAT3) - RPU53646 from Biomatik Category Protein Prices $198.00, $387.00, $619.00, $738.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

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