WNT5A

Gene Symbol	WNT5A
Entrez Gene	7474
Alt Symbol	hWNT5A
Species	Human
Gene Type	protein-coding
Description	wingless-type MMTV integration site family, member 5A
Other Description	WNT-5A protein|protein Wnt-5a
Swissprots	Q6P278 P41221 A8K4A4
Accessions	CAI38645 CAY02596 CAY86018 EAW65310 EAW65311 P41221 AI634753 AK021503 AK090582 BAG52191 AK290375 BAF83064 AK290869 BAF83558 AU118341 BC064694 AAH64694 BC074783 AAH74783 BF218039 BM728706 BU742635 DB224740 EF028086 ABK20872 HG495695 JF432410 ADZ15627 L20861 AAA16842 XM_006713324 XP_006713387 XM_011534081 XP_011532383 XM_011534082 XP_011532384 XM_011534083 XP_011532385 XM_011534084 XP_011532386 XM_011534085 XP_011532387 XM_011534086 XP_011532388 XM_011534087 XP_011532389 XM_011534088 XP_011532390 XM_011534089 XP_011532391 NM_001256105 NP_001243034 NM_003392 NP_003383
Function	Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes. {ECO:0000269|PubMed:15735754, ECO:0000269|PubMed:17426020}.
Subcellular Location	Secreted, extracellular space, extracellular matrix.
Tissue Specificity	Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level). {ECO:0000269|PubMed:15735754}.
Top Pathways	Proteoglycans in cancer, Wnt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Hippo signaling pathway, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Wnt5a/b (C27E8) Rabbit mAb - 2530 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone C27E8

Wnt5a Antibody - 2392 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

Wnt-5a (A-5) - sc-365370 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Wnt-5a (C-16) - sc-23698 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Wnt-5a (H-58) - sc-30224 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Wnt-5a/b (G-4) - sc-376249 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Anti-Wnt5a antibody - ab174963 from Abcam Prices $384.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-Wnt5a antibody - ab153876 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Wnt5a antibody [3D10] - ab86720 from Abcam Prices $390.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3D10

Anti-Wnt5a antibody [6F2] - ab110073 from Abcam Prices $384.00 Sizes 50 µl Host Mouse Clonality Monoclonal Clone 6F2

Anti-Wnt5a antibody [EPR12698] - C-terminal - ab179824 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR12698

Anti-Wnt5a antibody - N-terminal - ab186995 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-WNT5A Antibody (aa180-229) IHC-plus™ - LS-B4565 from LifeSpan Bioscience Prices $450.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-WNT5A Antibody (clone 6F2) IHC-plus™ - LS-B3859 from LifeSpan Bioscience Prices $395.00 Sizes 50 µl Host Mouse Clonality Monoclonal Clone 6F2

Anti-WNT5A Antibody (clone 3D10) IHC-plus™ - LS-B3878 from LifeSpan Bioscience Prices $395.00 Sizes 50 µl Host Mouse Clonality Monoclonal Clone 3D10

Anti-WNT5A Antibody (Leu270) - LS-C40264 from LifeSpan Bioscience Prices $395.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-WNT5A Antibody (aa274-295) - LS-C47474 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-WNT5A Antibody (clone IMG4M5E4) - LS-C148826 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone IMG4M5E4

Anti-WNT5A Antibody (aa38-380) - LS-C124811 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Rat Clonality Monoclonal

Anti-WNT5A Antibody (Internal) - LS-C210210 from LifeSpan Bioscience Prices $295.00 Sizes 250 µl Host Rabbit Clonality Polyclonal

Anti-WNT5A Antibody (aa192-221, AP) - LS-C273619 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNT5A Antibody (aa192-221, APC) - LS-C273620 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNT5A Antibody (aa192-221, Biotin) - LS-C273621 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNT5A Antibody (aa192-221, FITC) - LS-C273622 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNT5A Antibody - LS-C192934 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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