WNT5A

Gene Symbol	WNT5A
Entrez Gene	7474
Alt Symbol	hWNT5A
Species	Human
Gene Type	protein-coding
Description	wingless-type MMTV integration site family, member 5A
Other Description	WNT-5A protein|protein Wnt-5a
Swissprots	Q6P278 P41221 A8K4A4
Accessions	CAI38645 CAY02596 CAY86018 EAW65310 EAW65311 P41221 AI634753 AK021503 AK090582 BAG52191 AK290375 BAF83064 AK290869 BAF83558 AU118341 BC064694 AAH64694 BC074783 AAH74783 BF218039 BM728706 BU742635 DB224740 EF028086 ABK20872 HG495695 JF432410 ADZ15627 L20861 AAA16842 XM_006713324 XP_006713387 XM_011534081 XP_011532383 XM_011534082 XP_011532384 XM_011534083 XP_011532385 XM_011534084 XP_011532386 XM_011534085 XP_011532387 XM_011534086 XP_011532388 XM_011534087 XP_011532389 XM_011534088 XP_011532390 XM_011534089 XP_011532391 NM_001256105 NP_001243034 NM_003392 NP_003383
Function	Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes. {ECO:0000269|PubMed:15735754, ECO:0000269|PubMed:17426020}.
Subcellular Location	Secreted, extracellular space, extracellular matrix.
Tissue Specificity	Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level). {ECO:0000269|PubMed:15735754}.
Top Pathways	Proteoglycans in cancer, Wnt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Hippo signaling pathway, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat WNT5A ELISA Kit (Sandwich ELISA) - LS-F6742 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Rat WNT5A ELISA Kit - LS-F7141 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.055 ng/ml Range 0.156 - 10 ng/ml (depending on sample type)

Mouse WNT5A ELISA Kit - LS-F7146 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.31 ng/ml Range 0.781 - 50 ng/ml (depending on sample type)

Human WNT5A ELISA Kit (Sandwich ELISA) - LS-F12975 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Protein Wnt-5a (WNT5A), Human, ELISA Kit - CSB-EL026138HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.039 ng/ml Range 0.156 ng/ml-10 ng/ml

Protein Wnt-5a, WNT5A, Human, ELISA Kit - E1038h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Wingless Type MMTV Integration Site Family, Member 5A (WNT5A), Human, ELISA Kit - SEP549Hu from ARP American Research Products Category ELISA Kit Prices $711.00 Sizes 96 t Sensitivity 0.051ng/mL Range 0.156-10ng/mL

Wingless Type MMTV Integration Site Family, Member 5A (WNT5A), Human, CLIA Kit - SCP549Hu from ARP American Research Products Category CLIA Kit Prices $783.00 Sizes 96 t Sensitivity 0.054ng/mL Range 0.156-10ng/mL

Protein Wnt-5a, ELISA Kit - MBS283116 from MyBioSource Category ELISA Kit Prices $425.00, $720.00, $3,160.00, $6,055.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Wingless Type MMTV Integration Site Family, Member 5A (WNT5A), ELISA Kit - MBS2021935 from MyBioSource Category ELISA Kit Prices $435.00, $665.00, $910.00, $3,690.00, $6,650.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.055ng/mL Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Wingless Type MMTV Integration Site Family, Member 5A (WNT5A), ELISA Kit - MBS2021425 from MyBioSource Category ELISA Kit Prices $420.00, $640.00, $870.00, $3,510.00, $6,365.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of WNT5A is typically less than 0.33ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 0.78 -50ng/mL

Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) - MBS2023809 from MyBioSource Category ELISA Kit Prices $625.00, $845.00 Sizes 48 strip wells, 96 strip wells Sensitivity The minimum detectable dose of WNT5A is typically less than 0.058ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 0.156-10ng/mL. The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.312ng/mL, 0.156ng/mL.

wingless-type MMTV integration site family, member 5A, ELISA Kit - MBS901538 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.039 ng/ml. Range 0.156 ng/ml-10 ng/ml.

ELISA Kit for Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) - SEP549Mi from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.054ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Protein Wnt-5a(WNT5A) ELISA kit - CSB-EL026138HU from Cusabio Category ELISA Kit Sensitivity 0.039 ng/ml. Range 0.156 ng/ml-10 ng/ml

Rabbit WNT5A ELISA Kit - LS-F15713 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range To be determined

Rat WNT5A ELISA Kit (Sandwich ELISA) - LS-F15714 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.31 Range 0.156-10 ng/ml

Mouse WNT5A ELISA Kit (Sandwich ELISA) - LS-F15715 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.156-10 ng/ml

Wingless Type MMTV Integration Site Family, Member 5A (WNT5A), ELISA Kit - MBS2025493 from MyBioSource Category ELISA Kit Prices $420.00, $625.00, $855.00, $3,510.00, $6,365.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.058ng/mL. Range 0.156-10ng/mL. The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.312ng/mL, 0.156ng/mL.

Human, Mouse, Rat WNT5A ELISA Kit - abx258208 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Wingless Type MMTV Integration Site Family, Member 5A (WNT5A), Human, ELISA Kit - DL-WNT5A-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Wingless Type MMTV Integration Site Family, Member 5A (WNT5A), CLIA Kit - MBS2000725 from MyBioSource Category CLIA Kit Prices $470.00, $720.00, $985.00, $4,005.00, $7,215.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of this kit is typically less than 5.65pg/mL. Range 13.72-10000pg/mL

Wingless Type MMTV Integration Site Family, Member 5A (WNT5A), CLIA Kit - MBS2000981 from MyBioSource Category CLIA Kit Prices $440.00, $670.00, $915.00, $3,705.00, $6,680.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of this kit is typically less than 5.1pg/mL. Range 13.72-10000pg/mL

Wingless Type MMTV Integration Site Family, Member 5A (WNT5A), CLIA Kit - MBS2001133 from MyBioSource Category CLIA Kit Prices $450.00, $685.00, $940.00, $3,805.00, $6,855.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of this kit is typically less than 4.86pg/mL. Range 13.72-10000pg/mL

Human WNT5A ELISA Kit - abx570761 from Abbexa Category ELISA Kit Sensitivity 0.072 ng/ml Range 0.156 ng/ml - 10 ng/ml

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