WNT5A

Gene Symbol	WNT5A
Entrez Gene	7474
Alt Symbol	hWNT5A
Species	Human
Gene Type	protein-coding
Description	wingless-type MMTV integration site family, member 5A
Other Description	WNT-5A protein|protein Wnt-5a
Swissprots	Q6P278 P41221 A8K4A4
Accessions	CAI38645 CAY02596 CAY86018 EAW65310 EAW65311 P41221 AI634753 AK021503 AK090582 BAG52191 AK290375 BAF83064 AK290869 BAF83558 AU118341 BC064694 AAH64694 BC074783 AAH74783 BF218039 BM728706 BU742635 DB224740 EF028086 ABK20872 HG495695 JF432410 ADZ15627 L20861 AAA16842 XM_006713324 XP_006713387 XM_011534081 XP_011532383 XM_011534082 XP_011532384 XM_011534083 XP_011532385 XM_011534084 XP_011532386 XM_011534085 XP_011532387 XM_011534086 XP_011532388 XM_011534087 XP_011532389 XM_011534088 XP_011532390 XM_011534089 XP_011532391 NM_001256105 NP_001243034 NM_003392 NP_003383
Function	Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes. {ECO:0000269|PubMed:15735754, ECO:0000269|PubMed:17426020}.
Subcellular Location	Secreted, extracellular space, extracellular matrix.
Tissue Specificity	Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level). {ECO:0000269|PubMed:15735754}.
Top Pathways	Proteoglycans in cancer, Wnt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Hippo signaling pathway, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Wnt5a full length protein - ab193873 from Abcam Category Protein Prices $199.00 Sizes 2 µg Source Mammalian Species Human

Human Wnt5a full length protein - ab159811 from Abcam Category Protein Source Wheat germ Species Human

Human Wnt5a protein fragment - ab159812 from Abcam Category Protein Source Wheat germ Species Human

Wnt5a peptide - ab177859 from Abcam Category Peptide

WNT5A Antibody Blocking Peptide - LS-E7928 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

WNT5A Antibody Blocking Peptide - LS-E11228 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Wingless-type MMTV integration site family, member 5 Blocking Peptide - LS-E15178 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Wnt-5a Protein - H00007474-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human Wnt-5a Protein - H00007474-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

WNT5A-Antibody-Center-Blocking-peptide - BP5682c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

WNT5A Blocking Peptide - 33R-3274 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

WNT5A - H00007474-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

WNT5A - H00007474-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

WNT5A - H00007474-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Wingless Type MMTV Integration Site Family, Member 5A (WNT5A), Human - 20-9573 from ARP American Research Products Category Protein Prices $579.00 Sizes 50 µg Source E.coli Species Human

Recombinant Human WNT5A, GST-tagged - WNT5A-2052H from Creative Biomart Category Protein Source wheat germ

Recombinant Human WNT5A, MYC/DDK-tagged - WNT5A-2053H from Creative Biomart Category Protein Source HEK293 Cells

Recombinant Human WNT5A, GST-tagged - WNT5A-2055H from Creative Biomart Category Protein Source wheat germ

Recombinant Human WNT5A, StrepII-tagged - WNT5A-206H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) - RPP549Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) - RPP549Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) - RPP549Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) - RPP549Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Human Protein Wnt-5a(WNT5A) - CSB-YP026138HU CSB-EP026138HU CSB-BP026138HU CSB-MP026138HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Human Wnt5a full length protein - ab204627 from Abcam Category Protein Source E. coli Species Human

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