TNFSF10

Gene Symbol TNFSF10
Entrez Gene 8743
Alt Symbol APO2L, Apo-2L, CD253, TL2, TRAIL
Species Human
Gene Type protein-coding
Description tumor necrosis factor (ligand) superfamily, member 10
Other Description Apo-2 ligand|TNF-related apoptosis inducing ligand TRAIL|chemokine tumor necrosis factor ligand superfamily member 10|tumor necrosis factor (ligand) family, member 10|tumor necrosis factor apoptosis-inducing ligand splice variant delta|tumor necrosis factor ligand superfamily member 10
Swissprots A1Y9B3 P50591
Accessions ABK41891 CAH68809 CAL33971 CAZ39545 CCA94584 EAW78465 EAW78466 EAW78467 P50591 AK296085 BAG58840 AK309200 AK312742 BAG35612 AY312579 AAR16184 BC009795 BC020220 BC032722 AAH32722 BT019564 AAV38371 CR456895 CAG33176 DA041872 DA969653 DQ848564 ABI24016 DQ890873 ABM81799 DQ894029 ABM84955 EU183231 ABW24658 U37518 AAC50332 U57059 AAB01233 NM_001190942 NP_001177871 NM_001190943 NP_001177872 NM_003810 NP_003801 NR_033994
Function Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Subcellular Location Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Tissue Specificity Widespread; most predominant in spleen, lung and prostate.
Top Pathways Cytokine-cytokine receptor interaction, Apoptosis, Natural killer cell mediated cytotoxicity, Measles, Influenza A

TRAIL (C92B9) Rabbit mAb - 3219 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C92B9
Western blot analysis of extract from 786-0 cells and differentiated THP-1 cells, untreated or treated overnight with LPS, using TRAIL (C92B9) Rabbit mAb.

TRAIL (C-19) - sc-1889 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRAIL (C-19): sc-1889. Western blot analysis of human recombinant TRAIL fusion protein.

TRAIL (D-3) - sc-8440 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TRAIL (D-3): sc-8440. Western blot analysis of human recombinant TRAIL fusion protein.

TRAIL (H-257) - sc-7877 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TRAIL (H-257): sc-7877. Western blot analysis of TRAIL expression in A549 (A) and AT-3 (B) whole cell lysates.

TRAIL (K-18) - sc-6079 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRAIL (K-18): sc-6079. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse liver tissue showing membrane localization.

TRAIL (RIK-2) - sc-56246 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Anti-TRAIL antibody - ab2435 from Abcam

Prices $395.00
Sizes 1 ml
Host Rabbit
Clonality Polyclonal
ab2435 staining TRAIL in mouse mTRAIL expressing 2PK3 cells by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with paraformaldehyde and blocked with 0.5% a TNB blocking reagent for 1 hour at 25°C . Samples were incubated with primary antibody 1/100 in TNB for 12 hours at 4°C. An Alexa Fluor® 488-conjugated Goat polyclonal to rabbit IgG, dilution 1/250, was used as secondary antibody.See Abreview

Anti-TRAIL antibody - ab9959 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab9959 stained MDA-MB-231 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab9959 at 1µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-TRAIL antibody - ab42121 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TRAIL antibody (ab42121) at 1 µg/ml + A549 (Human lung adenocarcinoma epithelial cell line) Whole Cell Lysate (ab7910) at 10 µgSecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilutionPerformed under reducing conditions.

Anti-TRAIL antibody - ab65121 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
These images show A549 cells, stained with ab65121 at 1/500 - 1/1000 dilution; with and without the immunising peptide.

Anti-TRAIL antibody - ab42243 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TRAIL antibody (ab42243) at 1 µg/ml + A549 (Human lung adenocarcinoma epithelial cell line) Whole Cell Lysate (ab7910) at 10 µgSecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilutionPerformed under reducing conditions.

Anti-TRAIL antibody - ab2056 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of HeLa cell lysate containing 10, 2.5, or 1 ng of recombinant protein containing extracellular domain of TRAIL with anti-TRAIL at 1 µg/ml.

Anti-TRAIL antibody - ab26933 from Abcam

Host Chicken
Clonality Polyclonal
Anti-TRAIL antibody (ab26933) at 1/2000 dilution + TRIAL fusion protein at 1 µgSecondary Goat anti-IgY-HRP dilution:

Anti-TRAIL antibody [2E5] - ab2219 from Abcam

Prices $382.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E5
Apoptosis induced in JURKAT human T cell leukemia cell line by soluble recombinant human TRAIL is completely blocked by anti-human TRAIL (2E5). The neutralizing activity of the antibody 2E5 has been confirmed with various sources of soluble recombinant human TRAIL. A - medium B - recombinant TRAIL C - recombinant TRAIL + anti-human TRAIL (2E5; 0.06 µg/ml) D - recombinant TRAIL + anti-human TRAIL (2E5; 0.24 µg/ml) E - recombinant TRAIL + Isotype mouse IgG1 control

Anti-TRAIL antibody [2E5] (Phycoerythrin) - ab183474 from Abcam

Prices $372.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2E5

Anti-TRAIL antibody [55B709.3] - ab12124 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 55B709.3
Standard curve for TRAIL (Analyte: ab78818); dilution range 1pg/ml to 1µg/ml using Capture Antibody Mouse monoclonal [55B709.3] to TRAIL (ab12124) at 0.2µg/ml and Detector Antibody Rabbit polyclonal to TRAIL (ab9959) at 0.1µg/ml.

Anti-TRAIL antibody [75411.11] - ab10516 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 75411.11

Anti-TRAIL antibody [B-S23] - ab27382 from Abcam

Prices $372.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone B-S23

Anti-TRAIL antibody [B-S23] - ab47229 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone B-S23

Anti-TRAIL antibody [B-S23] (Biotin) - ab27322 from Abcam

Prices $378.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone B-S23
Ab27322, at a dilution of 10µl for 106 cells or 100 µl of whole blood, staining TRAIL by Flow Cytometry.

Anti-TRAIL antibody [B-S23] (Phycoerythrin) - ab47230 from Abcam

Prices $189.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone B-S23
ab47230 staining TRAIL in human peripheral blood monocytes by Flow Cytometry.Cells were fixed in paraformaldehyde, permeabilized using 0.1% saponin/ PBS.ab47230 used at a 1/10 dilution.1 = non stimulated2 = INF gamma stimulated 100U/ml3 = LPS stimulated 100ng/mlSee Abreview

Anti-TRAIL antibody [B-T24] - ab47232 from Abcam

Prices $370.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone B-T24

Anti-TRAIL antibody (Biotin) - ab83147 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TRAIL antibody [MM0580-6D44] - ab89794 from Abcam

Host Mouse
Clonality Monoclonal
Clone MM0580-6D44

Anti-TRAIL antibody [RIK-2] - Low endotoxin, Azide free - ab171261 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone RIK-2
Flow cytometric analysis of Human Trail transfected cells labeling TRAIL with ab171261 conjugated to PE (filled histogram). Appropriate isotype controls were used (open histogram). Total viable cells were used for analysis.
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