TNFSF10

Gene Symbol TNFSF10
Entrez Gene 8743
Alt Symbol APO2L, Apo-2L, CD253, TL2, TRAIL
Species Human
Gene Type protein-coding
Description tumor necrosis factor (ligand) superfamily, member 10
Other Description Apo-2 ligand|TNF-related apoptosis inducing ligand TRAIL|chemokine tumor necrosis factor ligand superfamily member 10|tumor necrosis factor (ligand) family, member 10|tumor necrosis factor apoptosis-inducing ligand splice variant delta|tumor necrosis factor ligand superfamily member 10
Swissprots A1Y9B3 P50591
Accessions ABK41891 CAH68809 CAL33971 CAZ39545 CCA94584 EAW78465 EAW78466 EAW78467 P50591 AK296085 BAG58840 AK309200 AK312742 BAG35612 AY312579 AAR16184 BC009795 BC020220 BC032722 AAH32722 BT019564 AAV38371 CR456895 CAG33176 DA041872 DA969653 DQ848564 ABI24016 DQ890873 ABM81799 DQ894029 ABM84955 EU183231 ABW24658 U37518 AAC50332 U57059 AAB01233 NM_001190942 NP_001177871 NM_001190943 NP_001177872 NM_003810 NP_003801 NR_033994
Function Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Subcellular Location Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Tissue Specificity Widespread; most predominant in spleen, lung and prostate.
Top Pathways Cytokine-cytokine receptor interaction, Apoptosis, Natural killer cell mediated cytotoxicity, Measles, Influenza A

TRAIL CRISPR/Cas9 KO Plasmid (h) - sc-418124 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAIL HDR Plasmid (h) - sc-418124-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAIL Double Nickase Plasmid (h) - sc-418124-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAIL Double Nickase Plasmid (h2) - sc-418124-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAIL CRISPR Activation Plasmid (h) - sc-418124-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAIL CRISPR Activation Plasmid (h2) - sc-418124-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAIL Lentiviral Activation Particles (h) - sc-418124-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAIL Lentiviral Activation Particles (h2) - sc-418124-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAIL siRNA (h) - sc-36719 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRAIL shRNA Plasmid (h) - sc-36719-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRAIL shRNA (h) Lentiviral Particles - sc-36719-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRAIL/TNFSF10 RNAi - H00008743-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU026121 from Sigma-Aldrich

Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN21759 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21759 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR13041 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr13041

TNFSF10 siRNA (Human) - CRH5761 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TNFSF10 - MBS8217765 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TNFSF10 (NM_003810.3) - SHH432088 from Creative biogene

Category siRNA
Species Reactivities Human

TNFSF10 shRNA Plasmid (Human) - CHH5761 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TNFSF10 miRNA 3'UTR clone - MiUTR3H-06100 from Creative biogene

Species Reactivities Human
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