TNFSF10

Gene Symbol	TNFSF10
Entrez Gene	8743
Alt Symbol	APO2L, Apo-2L, CD253, TL2, TRAIL
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor (ligand) superfamily, member 10
Other Description	Apo-2 ligand|TNF-related apoptosis inducing ligand TRAIL|chemokine tumor necrosis factor ligand superfamily member 10|tumor necrosis factor (ligand) family, member 10|tumor necrosis factor apoptosis-inducing ligand splice variant delta|tumor necrosis factor ligand superfamily member 10
Swissprots	A1Y9B3 P50591
Accessions	ABK41891 CAH68809 CAL33971 CAZ39545 CCA94584 EAW78465 EAW78466 EAW78467 P50591 AK296085 BAG58840 AK309200 AK312742 BAG35612 AY312579 AAR16184 BC009795 BC020220 BC032722 AAH32722 BT019564 AAV38371 CR456895 CAG33176 DA041872 DA969653 DQ848564 ABI24016 DQ890873 ABM81799 DQ894029 ABM84955 EU183231 ABW24658 U37518 AAC50332 U57059 AAB01233 NM_001190942 NP_001177871 NM_001190943 NP_001177872 NM_003810 NP_003801 NR_033994
Function	Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Tissue Specificity	Widespread; most predominant in spleen, lung and prostate.
Top Pathways	Cytokine-cytokine receptor interaction, Apoptosis, Natural killer cell mediated cytotoxicity, Measles, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TRAIL (CD253) Human ELISA Kit - ab46074 from Abcam Category ELISA Kit Prices $489.00, $734.00 Sizes 1 x 96 tests, 2 x 96 tests Sensitivity < 64 pg/ml Range 93.75 pg/ml - 3000 pg/ml

Human TNFSF10 / TRAIL ELISA Kit (Cell-Based ELISA) - LS-F3115 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 2.458-240 pg/ml

Human TNFSF10 / TRAIL ELISA Kit - LS-F6409 from LifeSpan Bioscience Category ELISA Kit Prices $470.00 Sizes 1 plate Sensitivity 0.067 ng/ml Range 0.156 - 10 ng/ml

Mouse TNFSF10 / TRAIL ELISA Kit (Sandwich ELISA) - LS-F6410 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 6.8 pg/ml Range 2.458-240 pg/ml

Dog TNFSF10 / TRAIL ELISA Kit (Sandwich ELISA) - LS-F6428 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.055 ng/ml Range 2.458-240 pg/ml

Rat TNFSF10 / TRAIL ELISA Kit (Sandwich ELISA) - LS-F6429 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.054 ng/ml Range 2.458-240 pg/ml

Human TNFSF10 / TRAIL ELISA Kit (Sandwich ELISA) - LS-F967 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 2.458-240 pg/ml

Mouse TNFSF10 / TRAIL ELISA Kit (Sandwich ELISA) - LS-F296 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 2.458 pg/ml Range 2.458-240 pg/ml

Human TNFSF10 / TRAIL ELISA Kit (Sandwich ELISA) - LS-F2563 from LifeSpan Bioscience Category ELISA Kit Prices $570.00 Sizes 1 plate Sensitivity 1 pg/ml Range 2.458-240 pg/ml

Human TNFSF10 / TRAIL ELISA Kit (Sandwich ELISA) - LS-F12789 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 46.9 Range 2.458-240 pg/ml

Human TRAIL/TNFSF10 Quantikine ELISA Kit - DTRL00 from R&D Systems Category ELISA Kit Prices $509.00 Sizes 1 kit Sensitivity 7.87 pg/mL Range 15.6 - 1,000 pg/mL (Cell Culture Supernates, Cell Lysates, Serum, EDTA Plasma, Heparin Plasma, Saliva)

Human TRAIL/TNFSF10 DuoSet ELISA - DY375 from R&D Systems Category ELISA Kit Prices $249.00, $649.00 Sizes 1 kit (for 5 Plates), 1 kit (for 15 Plates) Range 23.40 - 1,500 pg/mL

Mouse TRAIL/TNFSF10 DuoSet ELISA - DY1121 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 31.20 - 2,000 pg/mL

Quantikine Immunoassay Control Set 943 Human TRAIL/TNFSF10 - QC177 from R&D Systems Category ELISA Kit Prices $125.00 Sizes 1 each

Human TRAIL/TNFSF10 DuoSet, 5 Plate - DY375-05 from R&D Systems Category ELISA Kit

Human TRAIL ELISA kit - 55R-1695 from Fitzgerald Category ELISA Kit Prices $440.00 Sizes 1 kit

Human TRAIL ELISA kit - 55R-IB49673 from Fitzgerald Category ELISA Kit Prices $765.00 Sizes 96 wells

TRAIL/ApoII Ligand ELISA Kit (Human) : 96 Wells (OKAG00068) - OKAG00068 from Aviva Systems Biology Category ELISA Kit Prices $390.00 Sizes 96 wells Sensitivity 32 pg/mL Range 32-2,000 pg/mL

Human CD253 ELISA Kit - abx056081 from Abbexa Category ELISA Kit

Soluble tumor necrosis factor-related apoptosis inducing ligand, sTRAIL, Human, ELISA Kit - CSB-E04750h from ARP American Research Products Category ELISA Kit Prices $450.00, $595.00, $596.00, $599.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

TRAIL, Human, ELISA - IB49673 from ARP American Research Products Category ELISA Kit Prices $810.00 Sizes 96 t

TRAIL, Human, ELISA Kit - BEK1218 from ARP American Research Products Category ELISA Kit Prices $569.00 Sizes 96 t Sensitivity < 1pg/ml Range 15.6 pg/ml-1000 pg/ml

TRAIL, Human, ELISA Kit - PB-0532 from ARP American Research Products Category ELISA Kit Prices $449.00 Sizes 96 t Sensitivity < 1 pg/ml Range 15.6pg/ml-1000pg/ml

Tumor Necrosis Factor Related Apoptosis Inducing Ligand, TRAIL/TNFSF10, Human, ELISA Kit - E-EL-H1593 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 9.375 Range 15.625-1000pg/mL

Tumor necrosis factor ligand superfamily member 10, TNFSF10, Human, ELISA Kit - E0139h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 46.9-3000 pg/mL

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